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O-linked glycosylation is the attachment of a sugar molecule to the oxygen atom of serine (Ser) or threonine (Thr) residues in a protein. O -glycosylation is a post-translational modification that occurs after the protein has been synthesised.
O-linked glycans attached to the hydroxyl oxygen of serine, threonine, tyrosine, hydroxylysine, or hydroxyproline side-chains, or to oxygens on lipids such as ceramide. Phosphoglycans linked through the phosphate of a phosphoserine. C-linked glycans, a rare form of glycosylation where a sugar is added to a carbon on a tryptophan side-chain.
O-GlcNAc differs from other forms of protein glycosylation: (i) O-GlcNAc is not elongated or modified to form more complex glycan structures, (ii) O-GlcNAc is almost exclusively found on nuclear and cytoplasmic proteins rather than membrane proteins and secretory proteins, and (iii) O-GlcNAc is a highly dynamic modification that turns over more ...
The most common method of glycosylation of N-linked glycoproteins is through the reaction between a protected glycan and a protected Asparagine. [5] Similarly, an O-linked glycoprotein can be formed through the addition of a glycosyl donor with a protected Serine or Threonine. [5] These two methods are examples of natural linkage. [5]
An example of an O-linked oligosaccharide with β-Galactosyl-(1n3)-α-N-acetylgalactosaminyl-Ser/Thr. Oligosaccharides that participate in O-linked glycosylation are attached to threonine or serine on the hydroxyl group of the side chain. [7]
N-acetylation (N-terminus), N-linked ubiquitination, oxidation to sulfoxide or sulfone: Phenylalanine: Phe or F Proline: Pro or P hydroxylation: Serine: Ser or S phosphorylation, O-linked glycosylation, N-acetylation (N-terminus) Threonine: Thr or T phosphorylation, O-linked glycosylation, N-acetylation (N-terminus) Tryptophan: Trp or W
Salk Institute researchers have identified a key protein that may help users of GLP-1 drugs such as Ozempic and Wegovy maintain muscle mass while losing weight.
Protein O-GlcNAc transferase also known as OGT or O-linked N-acetylglucosaminyltransferase is an enzyme (EC 2.4.1.255) that in humans is encoded by the OGT gene. [ 5 ] [ 6 ] OGT catalyzes the addition of the O -GlcNAc post-translational modification to proteins .