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Megacolon is an abnormal dilation of the colon (also called the large intestine). [ 1 ] [ 2 ] This leads to hypertrophy of the colon. [ 2 ] The dilation is often accompanied by a paralysis of the peristaltic movements of the bowel.
Toxic megacolon is an acute form of colonic distension. [2] It is characterized by a very dilated colon ( megacolon ), accompanied by abdominal distension ( bloating ), and sometimes fever , abdominal pain , or shock .
Ogilvie syndrome, or acute colonic pseudo-obstruction, is the acute dilatation of the colon in the absence of any mechanical obstruction in severely ill patients. [1]Acute colonic pseudo-obstruction is characterized by massive dilatation of the cecum (diameter > 10 cm) and right colon on abdominal X-ray.
It may occur in chronic obstruction of stool transit, as in megacolon [10] and chronic constipation. Some diseases, such as Chagas disease, Hirschsprung's disease and others damage the autonomic nervous system in the colon's mucosa (Auerbach's plexus) and may cause extremely large or "giant" fecalomas, which must be surgically removed ...
Grade 1 colitis does not result in any symptoms, while grade 2 colitis leads to abdominal pain, mucous and blood in the stools. Grade 3 colitis is defined by severe pain, peritoneal signs and ileus. Grade 4 colitis is defined by life-threatening consequences, including perforation, ischemia, necrosis, bleeding, or toxic megacolon.
PSC does not parallel the onset, extent, duration, or activity of the colonic inflammation in ulcerative colitis. [34] In addition, colectomy does not have an impact on the course of primary sclerosing cholangitis in individuals with UC. [34] PSC is associated with an increased risk of colorectal cancer and cholangiocarcinoma (bile duct cancer).
For example, Shigella is a longstanding World Health Organization (WHO) target for vaccine development, and sharp declines in age-specific diarrhea/dysentery attack rates for this pathogen indicate that natural immunity does develop following exposure; thus, vaccination to prevent this disease should be feasible. The development of vaccines ...
Another helpful test to diagnose this condition may be an abdominal X-ray as this can show the distribution of feces and show any abnormalities with the colon, for example a megacolon. [14] Methods used for diagnosis may vary depending on if the patient is ncontinent or constipated. [citation needed]