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Horizontal gene transfer is the primary mechanism for the spread of antibiotic resistance in bacteria, [8] [5] [9] [10] and plays an important role in the evolution of bacteria that can degrade novel compounds such as human-created pesticides [11] and in the evolution, maintenance, and transmission of virulence. [12]
This lateral gene transfer occurred also beyond the Darwinian threshold, after heredity or vertical gene transfer was established. [4] [5] "Sequence comparisons suggest recent horizontal transfer of many genes among diverse species including across the boundaries of phylogenetic "domains". Thus determining the phylogenetic history of a species ...
Horizontal gene transfer was first observed in 1928, in Frederick Griffith's experiment: showing that virulence was able to pass from virulent to non-virulent strains of Streptococcus pneumoniae, Griffith demonstrated that genetic information can be horizontally transferred between bacteria via a mechanism known as transformation. [2]
Transformation is one of three processes that lead to horizontal gene transfer, in which exogenous genetic material passes from one bacterium to another, the other two being conjugation (transfer of genetic material between two bacterial cells in direct contact) and transduction (injection of foreign DNA by a bacteriophage virus into the host ...
An example is the viral transfer of DNA from one bacterium to another and hence an example of horizontal gene transfer. [2] [3] [page needed] Transduction does not require physical contact between the cell donating the DNA and the cell receiving the DNA (which occurs in conjugation), and it is DNase resistant (transformation is susceptible to ...
It is a mechanism of horizontal gene transfer as are transformation and transduction although these two other mechanisms do not involve cell-to-cell contact. [4] Classical E. coli bacterial conjugation is often regarded as the bacterial equivalent of sexual reproduction or mating since it involves the exchange of genetic material.
Horizontal gene transfer is the primary mechanism for the spread of antibiotic resistance in bacteria. Although homologous recombination varies widely among different organisms and cell types, for double-stranded DNA ( dsDNA ) most forms involve the same basic steps.
Bacterial conjugation is the transfer of genetic material (plasmid) between bacterial cells by direct cell-to-cell contact or by a bridge-like connection between two cells. [1] Discovered in 1946 by Joshua Lederberg and Edward Tatum, [ 2 ] conjugation is a mechanism of horizontal gene transfer as are transformation and transduction although ...