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2. Non-small-cell lung cancer - Wikipedia

   en.wikipedia.org/wiki/Non-small-cell_lung_cancer

   Non-small-cell lung cancer (NSCLC), or non-small-cell lung carcinoma, is any type of epithelial lung cancer other than small-cell lung cancer (SCLC). NSCLC accounts for about 85% of all lung cancers. [1] [2] [3] As a class, NSCLCs are relatively insensitive to chemotherapy, compared to small-cell carcinoma.

3. File:Pie chart of lung cancers.svg - Wikipedia

   en.wikipedia.org/wiki/File:Pie_chart_of_lung...

   English: Pie chart of the incidence of lung cancer types, sorted by histological subtypes, in turn sorted into how many are non-smokers versus smokers - defined as current or former smoker of more than 1 year of duration according to: Table 2 in: Kenfield SA, Wei EK, Stampfer MJ, Rosner BA, Colditz GA (2008).

4. Squamous-cell carcinoma of the lung - Wikipedia

   en.wikipedia.org/wiki/Squamous-cell_carcinoma_of...

   Squamous-cell lung carcinoma is one of the tumor types with the highest number of mutations since smoking, the main driver of the disease, is a strong mutagenic factor. [ 5 ] Inactivating mutations in lung SCC affect many tumor suppressor genes such as TP53 (mutated in 81% of cases), MLL2 (20%), CDKN2A (15%), KEAP1 (12%) and PTEN (8%).

5. Adenocarcinoma of the lung - Wikipedia

   en.wikipedia.org/wiki/Adenocarcinoma_of_the_lung

   Since smoking is a strong mutagenic factor, lung adenocarcinoma is one of the tumor types with the highest number of mutations. [12] Common somatic mutations in lung adenocarcinoma affect many oncogenes and tumor suppressor genes, including TP53 (mutated in 46% of cases), EGFR (27%), KRAS (32%), KEAP1, STK11 and NF1. [3]

6. Large-cell lung carcinoma - Wikipedia

   en.wikipedia.org/wiki/Large-cell_lung_carcinoma

   Pie chart showing incidence of large-cell lung cancer (shown in green at upper left) as compared to other lung cancer types, with fractions of smokers versus non-smokers shown for each type. [ 7 ] In most series, LCLC's comprise between 3%-9% of all primary lung cancers .

7. Tumor mutational burden - Wikipedia

   en.wikipedia.org/wiki/Tumor_mutational_burden

   In the lung, the median TMB across more than 18,000 lung cancer cases was 7.2 mutations/Mb, with approximately 12% of the patients showing more than 20 mutations/Mb. [24] The authors identified a tumor mutational burden greater than or equal to 10 mutations/Mb as the optimal cut-off to benefit from combination immunotherapy . [ 24 ]

8. 100+ Festive Holiday Desserts To Make Your Christmas Spread ...

   www.aol.com/97-festive-holiday-desserts...

   Peanut Butter Blossoms. As the story goes, a woman by the name of Mrs. Freda F. Smith from Ohio developed the original recipe for these for The Grand National Pillsbury Bake-Off competition in 1957.

9. Targeted therapy of lung cancer - Wikipedia

   en.wikipedia.org/wiki/Targeted_therapy_of_lung...

   Targeted agents are beginning to permit the design of more rational treatment regimens for non-small cell lung cancer (NSCLC), which comprises about 80% to 85% of all lung cancers. [ 3 ] [ 4 ] [ 18 ] While there have been no randomized clinical trials of targeted agents in combined small-cell lung carcinoma (c-SCLC), [ citation needed ] some ...