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A 500 mg laetrile tablet may contain between 2.5 and 25 mg of hydrogen cyanide. [16] Like amygdalin, laetrile is hydrolyzed in the duodenum (alkaline) and in the intestine (enzymatically) to D-glucuronic acid and L-mandelonitrile; the latter hydrolyzes to benzaldehyde and hydrogen cyanide, that in sufficient quantities causes cyanide poisoning ...
Ernst Theodore Krebs Jr. (May 17, 1911 – September 8, 1996) was an American promoter of various substances as alternative cures for cancer, including pangamic acid and amygdalin. He also co-patented the semi-synthetic chemical compound closely related to amygdalin called laetrile, which was
A pioneer in cancer research", [1] he completed over 250 papers before his death. Sugiura received a number of awards and prizes throughout his life, and retired from the center in 1962. He is perhaps best known for his work on laetrile, a controversial alternative cancer treatment, which he was convinced had a palliative effect on certain mice ...
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The enzyme amygdalin β-glucosidase (EC 3.2.1.117) catalyzes the following chemical reaction: ( R ) - amygdalin + H 2 O ⇌ {\displaystyle \rightleftharpoons } ( R )-prunasin + D -glucose Thus, the two substrates of this enzyme are ( R )- amygdalin and H 2 O , whereas its two products are ( R )- prunasin and D - glucose .
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The present ("Amygdalin") article states that amygdalin (a.k.a. laetrile/nitrilosides) is quackery and has no place in cancer treatment. Elsewhere, on the "Nitrile" Wiki page, it is stated that "Over 30 nitrile-containing pharmaceuticals are currently marketed for a diverse variety of medicinal indications with more than 20 additional nitrile ...
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