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Lithium orotate (C 5 H 3 LiN 2 O 4) is a salt of orotic acid and lithium.It is available as the monohydrate, LiC 5 H 3 N 2 O 4 ·H 2 O. [1] In this compound, lithium is non-covalently bound to an orotate ion, rather than to a carbonate or other ion, and like other salts, dissolves in solution to produce free lithium ions.
Orotic acid is a Bronsted acid and its conjugate base, the orotate anion, is able to bind to metals. Lithium orotate, for example, has been investigated for use in treating alcoholism, [4] [5] and complexes of cobalt, manganese, nickel, and zinc are known. [6]
7), lithium sulfate, lithium chloride, and lithium orotate. [139] [140] Nanoparticles and microemulsions have also been invented as drug delivery mechanisms. As of 2020, there is a lack of evidence that alternate formulations or salts of lithium would reduce the need for monitoring serum lithium levels or lower systemic toxicity. [139]
Lithium – Lithium is the "classic" mood stabilizer, the first to be approved by the US FDA, and still popular in treatment. Therapeutic drug monitoring is required to ensure lithium levels remain in the therapeutic range: 0.6 to 0.8 or 0.8–1.2 mEq/L (or millimolar).
3 Orotate? 2 comments. 4 Literature. 1 comment. 5 ... 6 Original research section moved from article. 1 comment. 7 Contradiction of toxic levels reached. 1 comment. 8 ...
Excessive levels of alcohol consumption increase risk for six cancers, from head and neck, to stomach cancers, the report said. In the U.S., more than 5% of cancers were linked to alcohol ...
The most common compounds used are lithium carbonate, Li 2 CO 3, lithium citrate, Li 3 C 6 H 5 O 7, lithium sulphate, Li 2 SO 4, and lithium orotate, LiC 5 H 3 N 2 O 4 ·H 2 O. Lithium is also used in batteries as an anode and its alloys with aluminium, cadmium, copper and manganese are used to make high performance parts for aircraft, most ...
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