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A protein is predicted to be "druggable" if it is a member of a protein family [4] for which other members of the family are known to be targeted by drugs (i.e., "guilt" by association). While this is a useful approximation of druggability, this definition has limitations for two main reasons: (1) it highlights only historically successful ...
993 12530 Ensembl ENSG00000164045 ENSMUSG00000032477 UniProt P30304 P48964 RefSeq (mRNA) NM_001789 NM_201567 NM_007658 RefSeq (protein) NP_001780 NP_963861 NP_031684 Location (UCSC) Chr 3: 48.16 – 48.19 Mb Chr 9: 109.7 – 109.72 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse M-phase inducer phosphatase 1 also known as dual specificity phosphatase Cdc25A is a protein that in ...
Protein phosphatase 1D is an enzyme that in humans is encoded by the PPM1D gene. [ 5 ] [ 6 ] The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases.
Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
PHLPP is a member of the PPM family of phosphatases, which requires magnesium or manganese for their activity and are insensitive to most common phosphatase inhibitors, including [okadaic acid]. PHLPP1 and PHLPP2 have a similar domain structure, which includes a putative Ras association domain, a pleckstrin homology domain , a series of leucine ...
Serine and threonine phosphates are stable under physiological conditions, so a phosphatase enzyme has to remove the phosphate to reverse the regulation signal. Ser/Thr-specific protein phosphatases are regulated partly by their location within the cell and by specific inhibitor proteins.
Many recent, large, well-conducted studies have shown no benefits in reducing fracture risk, cardiovascular disease, cancer prevention, or death from vitamin D supplementation,” Cutler said.
Low molecular weight phosphotyrosine protein phosphatase is an ... increased expression of ACP1 is a biomarker for poor prognosis in prostate cancer has been ...