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[7] [8] [9] Hence, IPAP is a representative selective serotonergic activity enhancer (SAE) at lower doses. [3] [2] IPAP is more potent as a MAE than PPAP and selegiline but is less potent than BPAP. [3] [2] As with BPAP and PPAP, the negative enantiomer (i.e., R(–)-IPAP) is more biologically active as a MAE and is often the employed compound. [3]
Positive airway pressure (PAP) is a mode of respiratory ventilation used in the treatment of sleep apnea.PAP ventilation is also commonly used for those who are critically ill in hospital with respiratory failure, in newborn infants (), and for the prevention and treatment of atelectasis in patients with difficulty taking deep breaths.
The term APRV has also been used in American journals where, from the ventilation characteristics, BIPAP would have been perfectly good terminology. [8] But BiPAP(tm) is a trademark for a noninvasive ventilation mode in a specific ventilator (Respironics Inc.). Other manufacturers have followed with their own brand names (BILEVEL, DUOPAP, BIVENT).
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[1] Airway pressure release ventilation was described initially by Stock and Downs in 1987 [2] [3] as a continuous positive airway pressure (CPAP) with an intermittent release phase. APRV begins at a pressure higher than the baseline pressure and follows with a deflation to accomplish tidal ventilation. [4]
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