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A major application of cellular adoptive therapy is cancer treatment, as the immune system plays a vital role in the development and growth of cancer. [1] The primary types of cellular adoptive immunotherapies are T cell therapies. Other therapies include CAR-T therapy, CAR-NK therapy, macrophage-based immunotherapy and dendritic cell therapy.
Cell therapy (also called cellular therapy, cell transplantation, or cytotherapy) is a therapy in which viable cells are injected, grafted or implanted into a patient in order to effectuate a medicinal effect, [1] for example, by transplanting T-cells capable of fighting cancer cells via cell-mediated immunity in the course of immunotherapy, or ...
Cellular manufacturing is a process of manufacturing which is a subsection of just-in-time manufacturing and lean manufacturing encompassing group technology. The goal of cellular manufacturing is to move as quickly as possible, make a wide variety of similar products, while making as little waste as possible.
Group technology or TZ is a manufacturing technique [1] in which parts having similarities in geometry, manufacturing process and/or functions are manufactured in one location using a small number of machines or processes. Group technology is based on a general principle that many problems are similar and by grouping similar problems, a single ...
Lights-out manufacturing is the methodology of fully automating the production of goods at factories and other industrial facilities, such as to require no human presence on-site. Many of these factories are considered to be able to run "with the lights off," but few run exclusively lights-out production.
This facilitates the final step in generation and implementation of both autologous and allogeneic CAR-T cell therapy. While this delivery method is reliable for hematologic cancers, as demonstrated by successful clinical trials and FDA regulation, systemic delivery may result in an increase in autoimmune overload, leading to toxic disorders ...
In mathematics and computability theory, an elementary cellular automaton is a one-dimensional cellular automaton where there are two possible states (labeled 0 and 1) and the rule to determine the state of a cell in the next generation depends only on the current state of the cell and its two immediate neighbors.
The device contains pancreatic progenitor cells that have been differentiated from embryonic stem cells. [39] After surgical implantation in an outpatient procedure, the cells mature into endocrine cells which arrange in islet-like clusters and mimic the function of the pancreas, producing insulin and glucagon.