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Infant respiratory distress syndrome (IRDS), also known as surfactant deficiency disorder (SDD), [2] and previously called hyaline membrane disease (HMD), is a syndrome in premature infants caused by developmental insufficiency of pulmonary surfactant production and structural immaturity in the lungs.
Severe deficiency of pulmonary surfactant due to disturbed metabolism of any of these proteins can lead to some form of interstitial lung disease in newborns and adults. These conditions share similar pathophysiology and overlapping phenotypes because surfactant gene products interactively communicate and control one another. [ 3 ]
However, surfactant decreases the alveolar surface tension, as seen in cases of premature infants with infant respiratory distress syndrome. The normal surface tension for water is 70 dyn/cm (70 mN/m) and in the lungs, it is 25 dyn/cm (25 mN/m); however, at the end of the expiration, compressed surfactant phospholipid molecules decrease the ...
Conditions adult respiratory distress syndrome or Hyaline Membrane Disease are also sometimes treated with exogenously derived surfactant. One of the more common uses of surfactant therapy is to treat alveolar surfactant deficiency in premature newborns. Most commonly, treatment is composed of multiple doses of 100 mg/kg of exogenous surfactant ...
John Allen Clements (March 16, 1923 – September 3, 2024) was an American physician and physiologist known for his role in the discovery of pulmonary surfactant, a crucial factor in the development of life-saving treatments for neonatal respiratory distress syndrome. His research revolutionized the care of premature infants, greatly reducing ...
A B12 deficiency can cause issue ranging from ... a blood condition that may be the culprit behind someone feeling tired and weak. ... starting with .5 mcg per day for infants up to 2.4 mcg for ...
[1] [2] [3] Lungs require surfactant, a soap-like substance, to lower the surface tension of the fluid coating the alveolar epithelium in the lungs. This is especially important for premature babies trying to expand their lungs after birth. Surfactant is a mixture of lipids, proteins, and glycoproteins, lecithin and sphingomyelin being two of ...
A group of parents have accused the state of New Jersey of “secretly retaining” their newborn babies’ blood in a “creepy database” without their consent.. In a news release, the non ...