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Pantoprazole, sold under the brand name Protonix, among others, is a medication used for the treatment of stomach ulcers, short-term treatment of erosive esophagitis due to gastroesophageal reflux disease (GERD), maintenance of healing of erosive esophagitis, and pathological hypersecretory conditions including Zollinger–Ellison syndrome.
PPIs are among the most widely sold medications in the world. The class of proton-pump inhibitor medications is on the World Health Organization's List of Essential Medicines . [ 7 ] [ 8 ] Omeprazole is the specific listed example.
The most common side effect seen is constipation (2–3%). Less commonly reported side effects (<0.5%) include flatulence, headache, hypophosphatemia, xerostomia (dry mouth), and bezoar formation. [24] [25] [26] Use of this drug is not recommended for people with chronic kidney failure, as it might cause aluminium accumulation and toxicity.
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One potential side effect of vagotomy is a vitamin B 12 deficiency. As vagotomy decreases gastric secretion, intrinsic factor production can be impaired. Intrinsic factor is needed to absorb vitamin B 12 efficiently from food, and injections or large oral doses of the vitamin may be required after such a procedure in certain populations. [19]