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Botulinum toxin can cause botulism, a severe flaccid paralytic disease in humans and other animals, [3] and is the most potent toxin known to science, natural or synthetic, with a lethal dose of 1.3–2.1 ng/kg in humans.
The toxin is the protein botulinum toxin produced under anaerobic conditions (where there is no oxygen) [37] by the bacterium Clostridium botulinum. [38] Clostridium botulinum is a large anaerobic Gram-positive bacillus that forms subterminal endospores. [39] There are eight serological varieties of the bacterium denoted by the letters A to H.
There were 52 confirmed deaths, including 19 stillbirths and 10 infant deaths. [ 2 ] [ 21 ] At the time, it was the deadliest foodborne illness outbreak in the United States, measured by the number of deaths, since the Centers for Disease Control and Prevention had begun tracking outbreaks in the 1970s. [ 2 ]
This is a list of foodborne illness outbreaks by death toll, caused by infectious disease, heavy metals, chemical contamination, or from natural toxins, such as those found in poisonous mushrooms. Before modern microbiology, foodbourne illness was not understood, and, from the mid 1800s to early-mid 1900s, was perceived as ptomaine poisoning ...
Waterborne diseases are conditions (meaning adverse effects on human health, such as death, disability, illness or disorders) [1]: 47 caused by pathogenic micro-organisms that are transmitted by water. These diseases can be spread while bathing, washing, drinking water, or by eating food exposed to contaminated water. [2]
Clostridium species are readily found inhabiting soils and intestinal tracts. Clostridium species are also a normal inhabitant of the healthy lower reproductive tract of females. [14] The main species responsible for disease in humans are: [15] Clostridium botulinum can produce botulinum toxin in food or wounds and can cause botulism.
Clostridium botulinum; Clostridium perfringens (previously called Clostridium welchii) ... List of human diseases associated with infectious pathogens
Clostridium botulinum; Note: Botulism is not an infection by Clostridium botulinum but caused by the intake of botulinum toxin. Botulism (and Infant botulism) Enzyme-linked immunosorbent assays (ELISAs), electrochemiluminescent (ECL) tests Botulism antitoxin and supportive care No Sabiá virus: Brazilian hemorrhagic fever: No Brucella species ...