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Metolazone is a thiazide-like diuretic marketed under the brand names Zytanix, Metoz, Zaroxolyn, and Mykrox. It is primarily used to treat congestive heart failure and high blood pressure . Metolazone indirectly decreases the amount of water reabsorbed into the bloodstream by the kidney , so that blood volume decreases and urine volume increases.
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The term "thiazide" is also often used for drugs with a similar action that do not have the thiazide chemical structure, such as chlorthalidone, metolazone and indapamide. These agents are more properly termed thiazide-like diuretics. [citation needed] Thiazide diuretics also increase calcium reabsorption at the distal tubule.
Bola Vithal Shetty (Dr.) is an India born American scientist who developed Metolazone [when?] and was associated with the Food and Drug Administration agency. [ 1 ] References
Chlorothiazide, sold under the brand name Diuril among others, is an organic compound used as a diuretic and as an antihypertensive. [1] [2]It is used both within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure.
After oral administration, 20 mg of xipamide are resorbed quickly and reach the peak plasma concentration of 3 mg/L within an hour. The diuretic effect starts about an hour after administration, reaches its peak between the third and sixth hour, and lasts for nearly 24 hours.
I'll do my best with the history, although history is notoriously difficult—especially for medical topics, where "history" has a special meaning and severly confounds searches. It's not easy to find information about the development of non-major drugs like metolazone.
From or to a drug trade name: This is a redirect from (or to) the trade name of a drug to (or from) the international nonproprietary name (INN).