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Splenomegaly is an enlargement of the spleen. [1] The spleen usually lies in the left upper quadrant (LUQ) of the human abdomen.Splenomegaly is one of the four cardinal signs of hypersplenism which include: some reduction in number of circulating blood cells affecting granulocytes, erythrocytes or platelets in any combination; a compensatory proliferative response in the bone marrow; and the ...
Splenic marginal zone lymphoma (SMZL) is a type of marginal zone lymphoma, a cancer made up of B-cells that replace the normal architecture of the white pulp of the spleen. The neoplastic cells are both small lymphocytes and larger, transformed lymphoblasts , and they invade the mantle zone of splenic follicles and erode the marginal zone ...
MZLs represent 5–17% of all Non-Hodgkin lymphomas with the extranodal, splenic, and nodal forms accounting for 50–70%, ~20%, and ~10% of all MZLs. [5] The three MZL subtypes occur more often in older people (age 65–68 years) and are indolent diseases that may, in people without symptoms, be initially treated by a watchful waiting strategy.
Non-Hodgkin lymphomas, which are defined as being all lymphomas except Hodgkin lymphoma, are more common than Hodgkin lymphoma. A wide variety of lymphomas are in this class, and the causes, the types of cells involved, and the prognoses vary by type. The number of cases per year of non-Hodgkin lymphoma increases with age.
Non-Hodgkin lymphoma (NHL), also known as non-Hodgkin's lymphoma, is a group of blood cancers that includes all types of lymphomas except Hodgkin lymphomas. [1] Symptoms include enlarged lymph nodes, fever, night sweats, weight loss, and tiredness. [1] Other symptoms may include bone pain, chest pain, or itchiness. [1]
Variant form of nodular lymphocyte predominant Hodgkin lymphoma T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is a malignancy of B cells . B-cells are lymphocytes that normally function in the humoral immunity component of the adaptive immune system by secreting antibodies that, for example, bind to and neutralize invasive pathogens .
Hodgkin lymphoma, mixed cellularity, NOS; M9653/3 Lymphocyte-depleted classical Hodgkin lymphoma, NOS M9654/3 Hodgkin lymphoma, lymphocyte depletion, diffuse fibrosis M9655/3 Hodgkin lymphoma, lymphocyte depletion, reticular M9659/3 Nodular lymphocyte predominant Hodgkin lymphoma. Hodgkin lymphoma, lymphocyte predominance, nodular; Hodgkin ...
Peripheral neuropathy occurs in 10% of patients. Enlargement of the lymph nodes, spleen, and/or liver are present in 30–40% of cases. [10] Other possible signs and symptoms include blurring or loss of vision, headache, and (rarely) stroke or coma. [citation needed]