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A foreign-body granuloma occurs when a foreign body (such as a wood splinter, piece of metal, glass etc.) penetrates the body's soft tissue followed by acute inflammation and formation of a granuloma. [18] In some cases the foreign body can be found and removed even years after the precipitating event. [19]
Granulomatous inflammation: Characterised by the formation of granulomas, they are the result of a limited but diverse number of diseases, which include among others tuberculosis, leprosy, sarcoidosis, and syphilis.
Chronic granulomatous disease (CGD), also known as Bridges–Good syndrome, chronic granulomatous disorder, and Quie syndrome, [1] is a diverse group of hereditary diseases in which certain cells of the immune system have difficulty forming the reactive oxygen compounds (most importantly the superoxide radical due to defective phagocyte NADPH oxidase) used to kill certain ingested pathogens. [2]
It usually includes the formation of a foreign body granuloma. [2] Tissue encapsulation of an implant is an example, as is inflammation around a splinter . [ 3 ] Foreign body granuloma formation consists of protein adsorption , macrophages , multinucleated foreign body giant cells (macrophage fusion), fibroblasts , and angiogenesis .
Langhans giant cell was typically associated with tuberculosis but has been found to occur in many types of granulomatous diseases. Langhans giant cell could be closely related to tuberculosis, syphilis, sarcoidosis, and deep fungal infections. Langhans giant cell occurs frequently in delayed hypersensitivity.
Microscopically, Aschoff bodies are areas of inflammation of the connective tissue of the heart, or focal interstitial inflammation.Fully developed Aschoff bodies are granulomatous structures consisting of fibrinoid change, lymphocytic infiltration, occasional plasma cells, and characteristically abnormal macrophages surrounding necrotic centres.
Older lesions begin to change into a pink color. Size commonly ranges from a few millimeters to centimeters, though smaller or larger lesions may occur. [medical citation needed] A pyogenic granuloma can be painful, especially if located in an area of the body where it is constantly disturbed. Pyogenic granulomas can grow rapidly and often ...
On histopathological examination, a biopsy will show leukocytoclastic vasculitis with necrotic changes and granulomatous inflammation (clumps of typically arranged white blood cells) on microscopy. These granulomas are the main reason for the name granulomatosis with polyangiitis, although it is not an essential feature.