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The procedure is to take the child's weight in pounds, divide by 150 lb, and multiply the fractional result by the adult dose to find the equivalent child dosage.For example, if an adult dose of medication calls for 30 mg and the child weighs 30 lb, divide the weight by 150 (30/150) to obtain 1/5 and multiply 1/5 times 30 mg to get 6 mg.
Acute use (1–3 days) yields a potency about 1.5× stronger than that of morphine and chronic use (7 days+) yields a potency about 2.5 to 5× that of morphine. Similarly, the effect of tramadol increases after consecutive dosing due to the accumulation of its active metabolite and an increase of the oral bioavailability in chronic use.
Adderall and Mydayis [11] are trade names [note 2] for a combination drug containing four salts of amphetamine.The mixture is composed of equal parts racemic amphetamine and dextroamphetamine, which produces a (3:1) ratio between dextroamphetamine and levoamphetamine, the two enantiomers of amphetamine. [13]
The conversion is rate-limited by the enzyme, which prevents high blood concentrations of dextroamphetamine and reduces lisdexamfetamine's drug liking and abuse potential at clinical doses. [ 236 ] [ 237 ] Vyvanse is marketed as once-a-day dosing as it provides a slow release of dextroamphetamine into the body.
The behavioral response to stimulants in children is similar regardless of whether they have ADHD or not. [38] Stimulant medication is an effective treatment [39] for adult attention-deficit hyperactivity disorder [40] [41] although the response rate may be lower for adults than children. [42]
The dosage may vary and is titrated to effect, with some guidelines recommending initial treatment with a low dose. [31] Methylphenidate is available in both immediate-release and extended-release (XR) formulations to provide a sustained release of the drug. [32] [33] Methylphenidate is not approved for children under six years of age. [34] [35]
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[1] [115] [166] The severity of overdose symptoms increases with dosage and decreases with drug tolerance to amphetamine. [41] [115] Tolerant individuals have been known to take as much as 5 grams of amphetamine in a day, which is roughly 100 times the maximum daily therapeutic dose. [115]