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  2. Furosemide - Wikipedia

    en.wikipedia.org/wiki/Furosemide

    Furosemide, sold under the brand name Lasix among others, is a loop diuretic medication used to treat edema due to heart failure, liver scarring, or kidney disease. [4] Furosemide may also be used for the treatment of high blood pressure. [4] It can be taken intravenously or orally. [4]

  3. Route of administration - Wikipedia

    en.wikipedia.org/wiki/Route_of_administration

    This can be illustrated by the action of naloxone (Narcan), an antagonist of opiates such as morphine. Naloxone counteracts opiate action in the central nervous system when given intravenously and is therefore used in the treatment of opiate overdose. The same drug, when swallowed, acts exclusively on the bowels; it is here used to treat ...

  4. Subcutaneous administration - Wikipedia

    en.wikipedia.org/wiki/Subcutaneous_administration

    Subcutaneous administration is the insertion of medications beneath the skin either by injection or infusion. A subcutaneous injection is administered as a bolus into the subcutis, the layer of skin directly below the dermis and epidermis, collectively referred to as the cutis. The instruments are usually a hypodermic needle and a syringe.

  5. Absorption (pharmacology) - Wikipedia

    en.wikipedia.org/wiki/Absorption_(pharmacology)

    As can be inferred from the Noyes–Whitney equation, the rate of dissolution may be modified primarily by altering the surface area of the solid by altering the particle size (e.g., with micronization). For many drugs, reducing the particle size reduces the dose needed to achieve the same therapeutic effect.

  6. Depot injection - Wikipedia

    en.wikipedia.org/wiki/Depot_injection

    Depot injections can be created by modifying the drug molecule itself, as in the case of prodrugs, or by modifying the way it is administered, as in the case of oil/lipid suspensions. Depot injections can have a duration of action of one month or greater and are available for many types of drugs, including antipsychotics and hormones.

  7. Osmotic diuretic - Wikipedia

    en.wikipedia.org/wiki/Osmotic_diuretic

    They are pharmacologically inert substances that are given intravenously. They increase the osmolarity of blood and renal filtrate. [1] This fluid eventually becomes urine. Two examples are mannitol [2] and isosorbide. In the nephron, osmotic diuretics act at the portions of the nephron that are water-permeable. [3]

  8. Discovery and development of beta2 agonists - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    When given subcutaneously adrenalin affects the whole body, giving various side effects and thus reducing the value of this treatment. The inhaled route was later tried and it gave much less adverse effects, but still had inconvenient side effects like fear, anxiety, restlessness, headache, dizziness and palpitation.

  9. Intradermal injection - Wikipedia

    en.wikipedia.org/wiki/Intradermal_injection

    The dosage given is usually less than 0.5 mL, less than given subcutaneously or intramuscularly. A 1 ⁄ 4 -to- 1 ⁄ 2 -inch-long (6 to 13 mm) and 26 or 27 gauge thick hypodermic needle is used. [ 1 ]

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