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In kidney impairment, clearance is reduced, increasing the risk of adverse effects. [4] Lower initial doses are recommended in older patients (to minimize side effects) and high doses may be needed in kidney failure. [26] It can also cause kidney damage; this is mainly by loss of excessive fluid (i.e., dehydration), and is usually reversible.
Nephrotoxicity is toxicity in the kidneys. It is a poisonous effect of some substances, both toxic chemicals and medications, on kidney function. [1] There are various forms, [2] and some drugs may affect kidney function in more than one way. Nephrotoxins are substances displaying nephrotoxicity.
[3] [5] Some of the muscle breakdown products, such as the protein myoglobin, are harmful to the kidneys and can cause acute kidney injury. [7] [3] The muscle damage is most usually caused by a crush injury, strenuous exercise, medications, or a substance use disorder. [3]
A bolus intravenous dose of 10 or 20 mg of furosemide can be administered and then followed by intravenous bolus of 2 or 3% hypertonic saline to increase the serum sodium level. [12] Pulmonary edema - Slow intravenous bolus dose of 40 to 80 mg furosemide at 4 mg per minute is indicated for patients with fluid overload and pulmonary edema. Such ...
Loop diuretics (furosemide, bumetanide, torasemide) and thiazide diuretics (e.g., chlortalidone, hydrochlorothiazide, or chlorothiazide) can increase kidney potassium excretion in people with intact kidney function. [38] Potassium can bind to a number of agents in the gastrointestinal tract.
These include sleep apnea, diabetes, high cholesterol, thyroid problems, and chronic kidney disease. ... but women have a higher risk than men in older age. ... can help people lose weight, ...
Certain underlying health conditions can increase the risk of gout as well: Kidney disease. Obesity. Diabetes. High blood pressure. Heart disease. Taking certain types of medications can ...
Hepatitis B: certain antigens present during hepatitis can accumulate in the kidneys and damage them. Sjögren's syndrome : this autoimmune disease causes the deposit of immunocomplexes in the glomeruli, causing them to become inflamed, this is the same mechanism as occurs in systemic lupus erythematosus.
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