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A pyridinecarboxylic acid is any member of a group of organic compounds which are monocarboxylic derivatives of pyridine. Pyridinecarboxylic acid comes in three isomers: Picolinic acid (2-pyridinecarboxylic acid) Nicotinic acid (3-pyridinecarboxylic acid), also known as Niacin; Isonicotinic acid (4-pyridinecarboxylic acid)
B(C 6 F 5) 3 forms a strong Lewis adduct with water, [5] which was shown to be a strong Brønsted acid having an acidity comparable to hydrochloric acid (in acetonitrile). [6] In consequence, even traces of moisture are able to deactivate B(C 6 F 5 ) 3 and remaining catalytic activity might only be due to the Brønsted acidity of the water adduct.
Boronic acids are known to bind to active site serines and are part of inhibitors for porcine pancreatic lipase, [2] subtilisin [3] and the protease Kex2. [4] Furthermore, boronic acid derivatives constitute a class of inhibitors for human acyl-protein thioesterase 1 and 2, which are cancer drug targets within the Ras cycle. [5]
Phenylboronic acid or benzeneboronic acid, abbreviated as PhB(OH) 2 where Ph is the phenyl group C 6 H 5 - and B(OH) 2 is a boronic acid containing a phenyl substituent and two hydroxyl groups attached to boron. Phenylboronic acid is a white powder and is commonly used in organic synthesis.
For the 2-pyridine boronic acid, the zwitterionic compound is responsible for its rapid protodeboronation under neutral pH, through a unimolecular fragmentation of the C-B bond. In fact, the addition of acid (H+) or hydroxide (OH-) acts to attenuate protodeboronation by shifting the speciation away from the reactive zwitterion.
5-(3-Pyridinylmethyl)benzofurancarboxylic acid, is an achiral, organic molecule containing a pyridine ring and a carboxylic acid group. The compound is a member of the benzofurans and can be found in a variety of forms (free-base, sodium salt and hydrochloric acid salt) all of them variations of the carboxylic acid functionality. [ 2 ]
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[5] B2pin2 and B2cat2. The boron atom of a boronic ester or acid is sp 2 hybridized possessing a vacant p orbital, enabling these groups to act as Lewis acids. The C–B bond of boronic acids and esters are slightly longer than typical C–C single bonds with a range of 1.55-1.59 Å.