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Static encephalopathy: Unchanging, or permanent, brain damage, usually caused by prenatal exposure to ethanol. Uremic encephalopathy: Arising from high levels of toxins normally cleared by the kidneys—rare where dialysis is readily available. Wernicke's encephalopathy: Arising from thiamine (B 1) deficiency, usually in the setting of alcoholism.
A name for the disease before the gene was identified was called static encephalopathy of childhood with neurodegeneration in adulthood (SENDA), though this term is no longer used. BPAN typically causes developmental delay and epilepsy from early childhood. An unusual feature experienced by many is a tendency to overeat without feeling full.
Ashley was born with a severe brain impairment of genetic cause, [2] termed a "static encephalopathy" because it does not improve.Although she sleeps and awakens, and breathes on her own, she is unable to raise her head, sit up, hold an object, walk, or talk, and must be tube-fed.
Fetal alcohol syndrome, partial fetal alcohol syndrome, alcohol-related neurodevelopmental disorder, static encephalopathy, alcohol-related birth defects [1] Causes: Drinking alcohol during pregnancy [1] Diagnostic method: Based on symptoms and prenatal alcohol exposure [1] Differential diagnosis
Esotropia is also known as dysconjugate gaze, and is a common feature of severe static encephalopathy. This differentiates BFPP from the other bilateral polymicrogyria syndromes. This differentiates BFPP from the other bilateral polymicrogyria syndromes.
The onset of seizures is between the ages of 2 and 5 years of age. EEG shows regular and irregular bilaterally synchronous 2- to 3-Hz spike-waves and polyspike patterns with a 4- to 7-Hz background. 84% of affected children show normal development prior to seizures; the remainder show moderate psychomotor retardation mainly affecting speech.
The symptoms variably include feelings of increased self-awareness, mental clarity, certainty, feelings of "unity with everything that exists" (including the external environment), intense positive affect, a sense of intense serenity or bliss, mystical, spiritual, or religious experiences, physical well-being, a sense of "hyper-reality", and time dilation, among others.
The clinical features and course of the condition, the associated auto-antibodies against relevant antigens, and the response to treatment, all suggest that Bickerstaff brainstem encephalitis is an autoimmune disease.