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The bone matrix is the intercellular substance of the bone that forms most of the mass of the bone. It consists of two types of material: organic and inorganic. The inorganic portion makes about half of the weight of the bone.
Cell-derived dECM, rich in collagen, matrix macromolecules, and growth factors, has good biocompatibility and biodegradability, making it beneficial for the proliferation and osteogenic differentiation of MSCs, and can be used as cell culture matrix for bone regeneration medicine.
Bone is a natural composite material whose main components are mineral and organic matrices 1, 2. The mature mineral matrix is in the form of nanosized, elongated platelet-like carbonated calcium...
Bone matrix refers to the matrix component of bone tissue. It provides the structural framework and mechanical support for bones, especially as it provides a site where new bone tissues are deposited during bone growth, remodeling, and repair. The bone matrix is made up of organic and inorganic components.
In this review we will address the current data about bone cells biology, bone matrix, and the factors that influence the bone remodeling process. Moreover, we will briefly discuss the role of estrogen on bone tissue under physiological and pathological conditions.
The bone matrix plays an indispensable role in the human body, and its unique biomechanical and mechanobiological properties have received much attention.
Bone matrix is a composite material that forms the structural framework of bone tissue. It consists of organic and inorganic materials, including mineral phase and collagen fibers. Understanding the components of bone matrix is crucial for comprehending the strength and composition of bones.
Over the past 30 years it has become apparent that the bone matrix is extremely rich in growth factors. Many of these, including TGFβ, IGFs, FGFs, PDGF and BMPs not only promote the growth of metastatic cancer cells in bone, but also increase the production and release of cytokines and other bone resorbing factors from tumour cells [1,41] .
Bone matrix is laid down by osteoblasts as collagen, also known as osteoid. Osteoid is hardened with inorganic salts, such as calcium and phosphate, and by the chemicals released from the osteoblasts through a process known as mineralization.
The extracellular matrix of bone is constructed by osteoblasts as a collagen-rich, fibrillar scaffold that subsequently mineralizes. In addition to collagen, bone matrix contains abundant noncollagenous proteins and small proteoglycans, some of which are thought to regulate the mineralization process.