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Monoclonal gammopathy of undetermined significance (MGUS) is a condition in which an atypical protein is found in the blood. The protein is called monoclonal protein or M protein. This protein is made in the soft, blood-producing tissue in the center of bones.
What is monoclonal gammopathy of undetermined significance (MGUS)? Monoclonal gammopathy of undetermined significance (MGUS) is a blood disorder that affects plasma cells in your bone marrow. Most of the time, M proteins don’t cause issues and most people with MGUS don’t have symptoms.
Monoclonal gammopathy of undetermined significance (MGUS) When bone marrow produces an unusual protein in the blood, it can sometimes lead to certain types of blood cancer.
Monoclonal gammopathy of undetermined significance (MGUS) is not cancer. There’s a small risk it can become cancer. Out of every 100 people with MGUS, each year, 1 or 2 of them will get cancer from MGUS. MGUS (pronounced like EM-gus) is when your blood makes an abnormal (not normal) protein called m-protein.
Monoclonal gammopathy of undetermined significance (MGUS) is a clinically asymptomatic premalignant clonal plasma cell or lymphoplasmacytic proliferative disorder.
Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic preneoplastic plasma cell disorder that is characterized by serum M-protein less than 30 g/L, bone marrow clonal plasma cells less than 10 percent, absence of plasma cell myeloma-related end-organ damage (hypercalcemia, renal insufficiency, anemia, or bone lesions) and ...
Disease Definition. pectrum of monoclonal plasma cell disorders (dyscrasias). MGUS is characterized by a monoclonal protein (M protein) < 3 g/dL (30 g/L) in the serum and < 10% monoclonal plasma cells in the bone marrow and no evidence of end-organ damage (“CRAB”: hypercalcemia, renal insuficiency, anemia or bone lesions), lymphoma, Walden.
Monoclonal gammopathy of undetermined significance (MGUS) is the production of M-protein by noncancerous plasma cells in the absence of other manifestations typical of multiple myeloma. (See also Overview of Plasma Cell Disorders.)
Monoclonal gammopathy of undetermined significance is an asymptomatic pre-malignant disorder associated with relatively low risk (on average 0.5% to 1.0% per year) of progression to multiple myeloma or related plasma cell proliferative malignancies. No aetiological risk factors have been defined.
Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant state for a spectrum of lymphoplasmacytic malignancies. The risk of progression of MGUS to a symptomatic therapy requiring plasma cell dyscrasia is about 1% per year.