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A dendritic cell (DC) is an antigen-presenting cell (also known as an accessory cell) of the mammalian immune system. A DC's main function is to process antigen material and present it on the cell surface to the T cells of the immune system. They act as messengers between the innate and adaptive immune systems. [1]
They are phagocytes and antigen-presenting or accessory cells (messengers and activators) in our innate and adaptive immune mechanisms. Dendritic cells are formed from precursor cells in the bone marrow and lymph tissue and are one of three types of antigen-presenting cells.
Dendritic cells (DC) constitute a unique system of cells able to induce primary immune responses. As a component of the innate immune system, DC organize and transfer information from the outside world to the cells of the adaptive immune system.
Dendritic cells (DCs), named for their probing, ‘tree-like’ or dendritic shapes, are responsible for the initiation of adaptive immune responses and hence function as the ‘sentinels’ of the immune system.
Dendritic cells (DCs) are professional antigen presenting cells that inform the fight against invasive pathogens while enforcing tolerance to self and harmless environmental antigens. They capture pathogens and receive signals from pathogens that influence the outcome of immune responses.
Dendritic cells represent a distinct type of white blood cells capable of alerting the immune system about the presence of infections and activating the innate and adaptive immune response. The term ‘dendritic cell’ was given due to the tree-like or dendritic appearance of the cell.
Dendritic cells (DCs) are the key link between innate immunity and adaptive immunity and play crucial roles in both the promotion of immune defense and the maintenance of immune...
Activated dendritic cells secrete cytokines that influence both innate and adaptive immune responses, making these cells essential gatekeepers that determine whether and how the immune system responds to the presence of infectious agents.
Dendritic cells are a multifunctional group of cells that serve as sentinels of the immune system and thus regulate many immune functions. * Dendritic cells play a central role in initiating adaptive immune responses to pathogens and initiating antitumor immune responses.
The function of dendritic cells (DCs) in linking innate to adaptive immunity is often summarized with two terms. DCs are sentinels, able to capture, process and present antigens and to migrate to lymphoid tissues to select rare, antigen-reactive T cell clones.
Dendritic cells (DCs) form a remarkable cellular network that shapes adaptive immune responses according to peripheral cues. After four decades of research, we now know that DCs arise from a hematopoietic lineage distinct from other leukocytes, establishing the DC system as a unique hematopoietic branch.
The innate immune system provides many ways to quickly resist infection. The two best-studied defenses in dendritic cells (DCs) are the production of protective cytokines-like interleukin (IL)-12 and type I interferons-and the activation and expansion of innate lymphocytes.
Dendritic cells (DCs) are antigen-presenting cells (APC) that act as messengers between the innate and the adaptive immune systems. They are present in tissues that are in contact with the external environment, but also in an immature state in the blood, and upon activation they migrate to the lymph nodes to interact with T-cells and B-cells.
From a physiological perspective, resistance to infection is not a single automatic response. Instead, dendritic cells select from a host of rapid, short-lived innate reactions and from the...
The immune system fights germs on the skin, in the tissues of the body, and in bodily fluids such as blood. It is made up of the innate (general) immune system and the adaptive (specialized) immune system. These two systems work closely together and take on different tasks.
Although there was “no flesh on the bones,” as I will recount later, the cell that interpreted the innate response to the adaptive system, the dendritic cell, had already been discovered by Ralph Steinman.
Dendritic cells (DC) constitute a unique system of cells able to induce primary immune responses. As a component of the innate immune system, DC organize and transfer information from the outside world to the cells of the adaptive immune system.
Dendritic cells (DCs) initiate and shape both the innate and adaptive immune responses. Accordingly, recent evidence from clinical studies and experimental models implicates DCs in the...
Dendritic cells (DCs) initiate and shape both the innate and adaptive immune responses. Accordingly, recent evidence from clinical studies and experimental models implicates DCs in the pathogenesis of most autoimmune diseases.
Dendritic cells (DCs) possess the ability to integrate information about their environment and communicate it to other leukocytes, shaping adaptive and innate immunity. Over the years, a variety of cell types have been called DCs on the basis of phenotypic and functional attributes.
Dendritic Cells (DCs) play a pivotal role in the immune system, acting as sentinels that capture, process and present antigens to T cells, thus initiating and regulating immune responses. Activation of DCs stands at the forefront as they work as coordinators of the immune system, spotting and presenting microbe fragments to T cells, thereby commencing Cell-Mediated Immunity (CMI).
Dendritic cells (DCs) have several functions in innate and adaptive immunity. In addition, there is increasing evidence that DCs in situ induce antigen-specific unresponsiveness or tolerance in central lymphoid organs and in the periphery. In the thymus DCs generate tolerance by deleting self-reactive T cells.
The innate immune system consists of various types of cells, such as granulocytes, NK cells, monocytes/macrophages, dendritic cells, and mast cells. Adaptive immune cells are broadly classified into B and T cells that can directly recognize antigens with great specificity.
As a rich store of F-actin, pyroptotic filopodia are recognized by dendritic cells through the F-actin receptor, CLEC9A (DNGR1). ... which coordinates the transition from innate to adaptive ...
Most clinical trials that have used dendritic cells as vaccine vehicles used low cellular doses. 35-37 In the current study, we documented that high (100 million) IT doses of autologous cDC1, which are meant to reprogram the TME, are safe and were associated with enhanced innate and adaptive immune effector infiltration of breast tumors that ...
Dose level 2 showed enhanced recruitment of adaptive CD3, CD4, and CD8 T cells and B cells within the tumor microenvironment (TME), along with increased innate gamma delta T cells and natural ...