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The antibody treatment, sasanlimab, in combination with Bacillus Calmette-Guérin (BCG) vaccine met the main goal of the study in patients with high-risk non-muscle invasive bladder cancer (NMIBC ...
“In bladder cancer, our work shows that PIN1 is important for bladder cancer cells to proliferate and grow, and to prevent the tumor cells from committing suicide by a process known as apoptosis ...
This is seen in about 75-85% patients of bladder cancer, the company said. Bladder cancer patients currently have to undergo a procedure called surgical ablation and either get chemotherapy or BCG ...
The safety and effectiveness of nadofaragene firadenovec was evaluated in a multicenter clinical study (Study CS-003 (NCT02773849)) that included 157 participants with high-risk Bacillus Calmette-Guérin (BCG)-unresponsive non-muscle-invasive bladder cancer, 98 of whom had BCG-unresponsive carcinoma in situ with or without papillary tumors and could be evaluated for response.
In general, the severity of cancer increases with a shorter duration of time between initial treatment and its return. [3] Cancers with the highest recurrence rates include Glioblastoma with a recurrence rate of almost 100%, [5] Epithelial ovarian cancer with a recurrence rate of 85%, [6] and Bladder cancer with a recurrence rate of 30-54% [7]
Bladder cancer is the abnormal growth of cells on the bladder. These cells, which originate in the urothelium, can grow to form a tumor, which eventually spreads, damaging the bladder and other organs. Most people with bladder cancer are diagnosed after noticing blood in their urine.
One of the oldest forms of cancer immunotherapy is the use of BCG vaccine, which was originally to vaccinate against tuberculosis and later was found to be useful in the treatment of bladder cancer. [13] BCG immunotherapy induces both local and systemic immune responses.
BCG vaccine has been the "standard of care for patients with bladder cancer (NMIBC)" since 1977. [35] [36] By 2014, more than eight different considered biosimilar agents or strains used to treat nonmuscle-invasive bladder cancer. [35] [36] Several cancer vaccines use BCG as an additive to provide an initial stimulation of the person's immune ...
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