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The Bacillus Calmette–Guérin (BCG) vaccine is a vaccine primarily used against tuberculosis (TB). [9] It is named after its inventors Albert Calmette and Camille Guérin . [ 10 ] [ 11 ] In countries where tuberculosis or leprosy is common, one dose is recommended in healthy babies as soon after birth as possible. [ 9 ]
Tuberculosis (TB) vaccines are vaccinations intended for the prevention of tuberculosis.Immunotherapy as a defence against TB was first proposed in 1890 by Robert Koch. [1] As of 2021, the only effective tuberculosis vaccine in common use is the Bacillus Calmette-Guérin (BCG) vaccine, first used on humans in 1921.
rBCG30 (recombinant Bacillus Calmette-Guérin 30) is a prospective Bacillus Calmette-Guérin vaccine against tuberculosis. It is a live vaccine, consisting of BCG , which has been evaluated as a tuberculosis vaccination.
The antibody treatment, sasanlimab, in combination with Bacillus Calmette-Guérin (BCG) vaccine met the main goal of the study in patients with high-risk non-muscle invasive bladder cancer (NMIBC ...
The only available vaccine as of 2021 is bacillus Calmette-Guérin (BCG). [ 115 ] [ 116 ] In children it decreases the risk of getting the infection by 20% and the risk of infection turning into active disease by nearly 60%.
The environment deemed appropriate for the denaturation of the Mycobacterium bovis was a compost of potatoes cooked in the bile of an ox treated with glycerine, and Calmette re-inseminated it every three weeks for thirteen years while checking for an enfeeblement of the pathogenic power of the bacillus.
A meta-analysis in 2014 found that the Bacillus Calmette–Guérin (BCG) vaccine reduced infections by 19–27% and reduced progression to active tuberculosis by 71%. [15] The Ohio Department of Health states that it give 80% of children protection against tuberculous meningitis and miliary tuberculosis.
Camille Guérin was born in Poitiers to a family of modest means. His father died of tuberculosis in 1882 (as well as his wife, in 1918). He studied veterinary medicine at the Ecole Nationale Vétérinaire d'Alfort from 1892 to 1896, working, while a student, as an assistant to pathologist Edmond Nocard (1850–1903).