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Most of the first generation microbicides were formulated as semi-solid systems, such as gels, tablets, films, or creams, and were designed to be applied to the vagina before every act of intercourse. However, vaginal rings have the potential to provide long-term controlled release of microbicide drugs.
It is commonly available without a prescription in various dosage forms, such as a topical cream, ointment, or vaginal suppository. [2] [7] It is also available as an oral troche or throat lozenge as a prescription only. Topically, clotrimazole is used for vulvovaginal candidiasis (yeast infection) or yeast infections of the skin. For ...
Clindamycin is formulated in a vaginal cream and as vaginal ovules for treatment of bacterial vaginosis. [39] It is also available for topical administration in gel form, as a lotion, and in a foam delivery system (each containing clindamycin phosphate ) and a solution in ethanol (containing clindamycin hydrochloride) and is used primarily as a ...
The metabolites show antibiotic and antiprotozoal activity in vitro. [61] Metronidazole and its metabolites are mainly excreted via the kidneys (77%) and to a lesser extent via the faeces (14%). [ 7 ] [ 8 ] The biological half-life of metronidazole in healthy adults is eight hours, in infants during the first two months of their lives about 23 ...
Miconazole, sold under the brand name Monistat among others, is an antifungal medication used to treat ring worm, pityriasis versicolor, and yeast infections of the skin or vagina. [2] It is used for ring worm of the body, groin (jock itch), and feet (athlete's foot). [2] It is applied to the skin or vagina as a cream or ointment. [2] [3]
Fenticonazole has also been shown to exhibit antibacterial action, with a spectrum of activity that includes bacteria commonly associated with superinfected fungal skin and vaginal infections, and antiparasitic action against the protozoan Trichomonas vaginalis. [1]
The vaginal flora consists of those organisms which generally do not cause symptoms and is dominated mainly by Lactobacillus species. [13] Disruption of the normal flora can cause a vaginal yeast infection. Vaginal yeast infection can affect women of all ages and is very common. The yeast Candida albicans is the most common cause of vaginitis ...
This study focused on the drug as an 80 mg vaginal suppository, taken three times overnight by 10 women. [4] In another placebo-controlled, double blind study by Schmidt et al., the efficacy of different concentrations of terconazole creams were tested. Cream was applied for three days to 24 women between the ages of 18 and 60.
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