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Liver failure; Pancreatitis (these two usually occur in first 6 months and can be fatal); Leukopenia (low white blood cell count); Neutropenia (low neutrophil count); Pure red cell aplasia
Valproate (valproic acid, VPA, sodium valproate, and valproate semisodium forms) are medications primarily used to treat epilepsy and bipolar disorder and prevent migraine headaches. [7] They are useful for the prevention of seizures in those with absence seizures , partial seizures , and generalized seizures . [ 7 ]
Reversible dementia; Reversible cerebral atrophy; Abnormal behaviour [b]; Psychomotor hyperactivity [b]; Learning disorder [b]; Hyperammonaemia; Hypothyroidism; Bone marrow failure
Valproic acid, and its derivatives such as sodium valproate and divalproex sodium, causes cognitive deficit in the child, with an increased dose causing decreased intelligence quotient and use is associated with adverse neurodevelopmental outcomes (cognitive and behavioral) in children.
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However, further research in older children and adults is needed. [18] [19] [20] Sodium valproate has been associated with paroxysmal tonic upgaze of childhood, also known as Ouvrier–Billson syndrome, from childhood or fetal exposure. This condition resolved after discontinuing valproate therapy.
Valproic acid, or valproate, was one of the first anti-convulsants tested for use in bipolar disorder. It has proven to be effective for treating acute mania. [2] The mania prevention and antidepressant effects of valproic acid have not been well demonstrated. [2] Valproic acid is less effective than lithium at preventing and treating ...
Sodium valproate [note 1] Convulex, Depakene, Depakine Enteric, Orfiril, Stavzor Divalproex sodium [note 2] Depakote, Epival, Ergenyl Chrono Sodium valproate and valproic acid in 2.3:1 ratio: Depakine Chrono, Depakine Chronosphere, Epilim Chrono, Epilim Chronosphere