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Praziquantel is not licensed for use in humans in the UK, but it can be imported when necessary on a named-patient basis. [35] It is available in the UK as a veterinary anthelmintic. Praziquantel is FDA approved in the US for the treatment of schistosomiasis and liver flukes, although it is effective in other infections. [36]
Oxamniquine acts mainly on male worms, but also induces small changes on a small proportion of females. Like praziquantel, it promotes more severe damage of the dorsal tegument than of the ventral surface. The drug causes the male worms to shift from the mesenteric circulation to the liver, where the cellular host response causes its final ...
Arpraziquantel ((R)-praziquantel) is the eutomer (the biologically active enantiomer) of praziquantel, and is a medication which is currently under investigation for the treatment of schistosomiasis in young children since it has less side effects than the usual racemic mixture formulation of praziquantel.
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Praziquantel – effective against flatworms (e.g., tapeworms and schistosoma) Octadepsipeptides (e.g. Emodepside) – effective against a variety of gastrointestinal helminths; Monepantel (aminoacetonitrile class) – effective against a variety of nematodes including those resistant to other anthelmintic classes
The prescription drug Praziquantel is usually prescribed in a single dose to patients infected with H.nana. Praziquantel is widely used and preferred due to its high efficacy. Research has shown that the cysticercoid phase of H.nana's life cycle is the most susceptible to the Praziquantel treatment. [2]
Praziquantel has some side effects but they are generally relatively mild and transient and a review of evidence shows it overall a well-tolerated drug. Possible side effects include abdominal pain , allergy , diarrhea , headache , liver problems , nausea or vomiting , exacerbation of porphyries , pruritus , rash , somnolence , vertigo , or ...
In humans, symptoms can include abdominal pain, diarrhea and weight loss. However, many infected individuals may be asymptomatic. Eurytrematosis is diagnosed through fecal examination for the presence of trematode eggs. Treatment typically involves the use of anthelmintic drugs such as praziquantel, which can effectively kill the adult parasites.
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