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HLA-DQ recognition of gliadin is critical to the pathogenesis of gluten-sensitive enteropathy, it also appears to be involved in idiopathic gluten sensitivity (See Understanding DQ haplotypes and DQ isoforms on the right). HLA-DQ2 primarily presents gliadins with the HLA-DQ isoform DQ2.5 (DQ α5-β2) isoform. DQA1*0202:DQB1*0201 homozygotes (DQ ...
Latiglutenase (IMGX003) is a biotheraputic digestive enzyme therapy currently being trialled that aims to degrade gluten proteins and aid gluten digestion. It was shown to mitigate intestinal mucosal damage and reduce the severity and frequency of symptoms in phase 2 clinical trials [ 176 ] and is scheduled for phase 3 clinical trials.
Non-celiac gluten sensitivity (NCGS) or gluten sensitivity [14] is a controversial disorder which can cause both gastrointestinal and other problems. NCGS is included in the spectrum of gluten-related disorders. [3] [4] The definition and diagnostic criteria of non-celiac gluten sensitivity were debated and established by three consensus ...
Unsurprisingly, hard red winter wheat has a higher gluten content than soft winter wheat, making it likely harder to digest for all us gluten-sensitives out there. Donato Fasano - Getty Images ...
Non-celiac gluten sensitivity (NCGS), or gluten intolerance, [1] is a syndrome in which people develop a variety of intestinal and/or extraintestinal symptoms that improve when gluten is removed from the diet, [32] after coeliac disease and wheat allergy are excluded. [33]
Another carbohydrate intolerance caused by enzyme deficiency is hereditary fructose intolerance. Celiac disease, an autoimmune disorder caused by an immune response to the protein gluten, results in gluten intolerance and can lead to temporary lactose intolerance. [27] [28]
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