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One ERCC1 molecule and one XPF molecule bind together, forming an ERCC1-XPF heterodimer which is the active nuclease form of the enzyme. In the ERCC1–XPF heterodimer, ERCC1 mediates DNA– and protein–protein interactions. XPF provides the endonuclease active site and is involved in DNA binding and additional protein–protein interactions. [9]
Excision may refer to: In surgery, the partial removal of an organ, tissue, bone or tumor from a body; Type II female genital mutilation; A term used by the Australian government as part of its definition of the Australian migration zone; Excision theorem in algebraic topology, a branch of mathematics
Exeresis may refer to the surgical removal of any part or organ, roughly synonymous to excision. [1] However, it may specifically refer to clearing the uterus of its contents after a miscarriage , such as vacuum aspiration .
Complete circumferential peripheral and deep margin assessment (CCPDMA) is the preferred method for the removal of certain cancers, especially skin cancers. [1] [2]There are two forms of CCPDMA surgery: Mohs surgery and surgical excision coupled with margin assessment.
Prostatectomy (from the Greek προστάτης prostátēs, "prostate" and ἐκτομή ektomē, "excision") is the surgical removal of all or part of the prostate gland. This operation is done for benign conditions that cause urinary retention, as well as for prostate cancer and for other cancers of the pelvis.
These are retained after the surgery and examined microscopically by a pathologist to see if the margin is indeed free from tumor cells (called "negative"). If cancerous cells are found at the edges (called "positive") the operation is much less likely to achieve the desired results.
Extirpation of the appendix, or appendectomy, is the standard treatment utilized in cases of acute appendicitis. [3] [4] Approximately 300,000 individuals in the United States have their appendix removed each year.
Central duct excision is the surgical removal (excision) of all lactiferous duct under the nipple. The excision of a single duct is called microdochectomy , a mere incision of a mammary duct (without excision) is microdochotomy .