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Gross examination of a kidney (right of image) with a renal oncocytoma (left of image).. Gross processing, "grossing" or "gross pathology" is the process by which pathology specimens undergo examination with the bare eye to obtain diagnostic information, as well as cutting and tissue sampling in order to prepare material for subsequent microscopic examination.
The Glomerular filtration rate (GFR) is regarded as the best overall measure of the kidney's ability to carry out these numerous functions. An estimate of the GFR is used clinically to determine the degree of kidney impairment and to track the progression of the disease. The GFR, however, does not reveal the source of the kidney disease.
For example, a patient complaining of urinary urgency (or rushing to the toilet), with increased frequency of urination can have overactive bladder syndrome. The cause of this might be detrusor overactivity, in which the bladder muscle (the detrusor) contracts unexpectedly during bladder filling. Urodynamics can be used to confirm the presence ...
The most common type of cast, hyaline casts are solidified Tamm–Horsfall mucoprotein secreted from the tubular epithelial cells of individual nephrons. Low urine flow, concentrated urine, or an acidic environment can contribute to the formation of hyaline casts, and as such, they may be seen in normal individuals in dehydration or vigorous exercise.
Determination of how much urine is in the bladder, for example to assess for urinary retention. To look for evidence and the cause of chronic kidney disease, for example shrunken kidneys. [1] To assist with an interventional procedure, such as the taking of a biopsy, or draining of an abscess or cyst. [1] To monitor a kidney transplant. [1]
A pathologist or pathology scientist may be present at the biopsy to examine the core(s) of kidney tissue for adequacy under a low power microscope. They will inform the person performing the procedure about how much kidney tissue was obtained, specifically how of biopsy sample is kidney cortex and how much is kidney medulla. In some centres ...
Renal pathology is a subspecialty of anatomic pathology that deals with the diagnosis and characterization of medical diseases (non-tumor) of the kidneys. In the academic setting, renal pathologists work closely with nephrologists and transplant surgeons , who typically obtain diagnostic specimens via percutaneous renal biopsy .
Urine pH may be monitored to help prevent the formation of kidney stones or to avoid side effects of some drugs, [68] such as high-dose methotrexate therapy, in which crystals that cause kidney damage can form if the urine is acidic. [69] If microscopy is performed, knowing the pH of the sample helps to identify any crystals that might be ...