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Thyroglobulin antibodies are specific for thyroglobulin, a 660 kDa matrix protein involved in the process of thyroid hormone production. They are found in 70% of Hashimoto's thyroiditis, 60% of idiopathic hypothyroidism, 30% of Graves' disease, a small proportion of thyroid carcinoma and 3% of normal individuals.
Thyroid function tests (TFTs) is a collective term for blood tests used to check the function of the thyroid. [1] TFTs may be requested if a patient is thought to suffer from hyperthyroidism (overactive thyroid) or hypothyroidism (underactive thyroid), or to monitor the effectiveness of either thyroid-suppression or hormone replacement therapy.
Reference ranges often depend on the analytical method used, for reasons such as inaccuracy, lack of standardisation, lack of certified reference material and differing antibody reactivity. [11] Also, reference ranges may be inaccurate when the reference groups used to establish the ranges are small. [12]
1.1-8.8 × 10 −11: Angiotensin II: Vasoconstrictor: 1.2-3.6 × 10 −11: Alpha 1-antitrypsin: Serine protease inhibitor 7.8-20 × 10 −4: Arginine: Amino acid 6-17 × 10 −6: 1.3-3.6 × 10 −5: Arsenic: normal range 2-62 × 10 −9: chronic poisoning 100-500 × 10 −9: acute poisoning 600-9300 × 10 −9: Ascorbic acid (Vitamin C ...
Anti-histone antibodies are autoantibodies that are a subset of the anti-nuclear antibody family, which specifically target histone protein subunits or histone complexes. [1] They were first reported by Henry Kunkel , H.R. Holman, and H.R.G. Dreicher in their studies of cellular causes of lupus erythematosus in 1959–60.
Schematic representation of a protein electrophoresis gel. Alpha globulins are a group of globular proteins in plasma [1] that are highly mobile in alkaline or electrically charged solutions.
Anti-Scl-70 (also called anti-topoisomerase I after the type I topoisomerase target [1]) is an anti-topoisomerase antibody-type of anti-nuclear autoantibodies, seen mainly in diffuse systemic scleroderma (with a sensitivity of 28–70%), but is also seen in 10–18% of cases of the more limited form of systemic scleroderma called CREST syndrome. [2]
Defects in the CD43 molecule are associated with the development of Wiskott–Aldrich syndrome. [8] It also appears in about 25% of intestinal MALTomas. [citation needed] Using immunohistochemistry, CD43 can be demonstrated in the paracortical T-cells of healthy lymph nodes and tonsils; it is also positive in a range of lymphoid and myeloid tumours.
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