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It was established in 2002 [1] and covers drug discovery and development. The editor-in-chief is Peter Kirkpatrick. [ 2 ] According to the Journal Citation Reports , the journal has a 2021 impact factor of 112.288, ranking it 1st out of 158 journals in the category "Biotechnology & Applied Microbiology" [ 3 ] and 1st out of 279 journals in the ...
Forward (classical) and reverse pharmacology approaches in drug discovery. In the field of drug discovery, classical pharmacology, [1] also known as forward pharmacology, [2] [3] [4] or phenotypic drug discovery (PDD), [5] relies on phenotypic screening (screening in intact cells or whole organisms) of chemical libraries of synthetic small molecules, natural products or extracts to identify ...
Nat Rev Drug Discov 2005; 4: 6: 461-7 Debes GF, Arnold CN, Young AJ, Krautwald S, Lipp M, Hay JB, Butcher EC "Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues." Nat Immunol 2005; 6: 9: 889-94
Azacitidine is the first drug to be approved by FDA for treating MDS and has been given orphan drug status. [ 2 ] [ 3 ] Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. [ 4 ]
Tachykinin peptides are one of the largest families of neuropeptides, found from amphibians to mammals.They were so named due to their ability to rapidly induce contraction of gut tissue. [2]
Min Zhuo. Min Zhuo (born 1964) is a pain neuroscientist at the University of Toronto in Canada. [1] He is the Michael Smith Chair in Neuroscience and Mental Health as well as the Canada Research Chair in Pain and Cognition and a Fellow of the Royal Society of Canada.
A national study discovered that teens in the United States consumed significantly less alcohol and drugs in 2024 compared to past years. Teen alcohol use has steadily decreased from 2000 to 2024 ...
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