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Tryptase is involved with allergenic response and is suspected to act as a mitogen for fibroblast lines. Tryptase may use the morpheein model of allosteric regulation. [10] Mast cell tryptase-6 is involved in Trichinella spiralis infection in mice through linking adaptive and innate immunity. [11]
17229 Ensembl ENSG00000197253 ENSMUSG00000033825 UniProt P20231 P21845 RefSeq (mRNA) NM_024164 NM_010781 RefSeq (protein) NP_077078 NP_034911 Location (UCSC) Chr 16: 1.23 – 1.23 Mb Chr 17: 25.59 – 25.59 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tryptase beta-2, also known as tryptase II, is a proteolytic enzyme that in humans is encoded by the TPSB2 gene. Formerly, the ...
17229 Ensembl ENSG00000095917 ENSMUSG00000033825 UniProt Q9BZJ3 P21845 RefSeq (mRNA) NM_012217 NM_010781 RefSeq (protein) NP_036349 NP_034911 Location (UCSC) Chr 16: 1.26 – 1.26 Mb Chr 17: 25.59 – 25.59 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tryptase delta is an enzyme that in humans is encoded by the TPSD1 gene. Tryptases comprise a family of trypsin-like serine ...
Tryptase alpha-1 and tryptase beta-1 are enzymes that in humans are encoded by the same TPSAB1 gene. [ 5 ] [ 6 ] Beta tryptases appear to be the main isoenzymes expressed in mast cells ; whereas in basophils , alpha tryptases predominate.
Total serum tryptase is elevated in mast cell leukemia. Normal total (alpha + beta) serum tryptase is approximately 6 micro g/L (range 0 to 11 micro g/L). Values of several hundred micro g/L are characteristic of mast cell leukemia. [12] Plasma and urinary histamine levels are frequently elevated in mast cell leukemia.
70835 Ensembl ENSG00000005001 ENSG00000282937 ENSMUSG00000045027 UniProt Q9GZN4 Q9ER10 RefSeq (mRNA) NM_022119 NM_133731 RefSeq (protein) NP_071402 NP_598492 Location (UCSC) Chr 16: 2.85 – 2.86 Mb Chr 17: 24.21 – 24.22 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Brain-specific serine protease 4 (BSSP-4), also known as serine protease 22 or tryptase epsilon, is an enzyme that ...
Chymases (EC 3.4.21.39, mast cell protease 1, skeletal muscle protease, skin chymotryptic proteinase, mast cell serine proteinase, skeletal muscle protease) are a family of serine proteases found primarily in mast cells, though also present in basophil granulocytes (e.g. alpha chymase mcpt8).
A mast cell (also known as a mastocyte or a labrocyte [1]) is a resident cell of connective tissue that contains many granules rich in histamine and heparin.Specifically, it is a type of granulocyte derived from the myeloid stem cell that is a part of the immune and neuroimmune systems.