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According to the cardiocentric hypothesis, the heart is the primary location of human emotions, cognition, and awareness. [1] This notion may be traced back to ancient civilizations such as Egypt and Greece, where the heart was regarded not only as a physical organ but also as a repository of emotions and wisdom. [2]
The constant communication between the heart and the brain have proved invaluable to the interdisciplinary fields of neurological and cardiac diseases. [4] The fundamental understanding of the communication between the heart and the brain via the nervous system has led scientists towards an understanding of its elaborate circuitry.
For example, brain–gut interactions are biochemical signaling that takes place between the gastrointestinal tract and the central nervous system. [2] Brain–heart interactions link cardiac physiology to activity in the central and peripheral nervous system and may explain how peripheral cardiovascular arousal can influence decision making ...
HCN4 is the main isoform expressed in the sinoatrial node, but low levels of HCN1 and HCN2 have also been reported.The current through HCN channels, called the pacemaker current (I f), plays a key role in the generation and modulation of cardiac rhythmicity, [13] as they are responsible for the spontaneous depolarization in pacemaker action potentials in the heart.
These form the ventricular system of the brain: [8] The neural stem cells of the developing brain, principally radial glial cells, line the developing ventricular system in a transient zone called the ventricular zone. [9] The prosencephalon divides into the telencephalon, which forms the cortex of the developed brain, and the diencephalon.
[1] [2] This means that all atrial cells can contract together, and then all ventricular cells. Different shapes of the cardiac action potential in various parts of the heart Rate dependence of the action potential is a fundamental property of cardiac cells and alterations can lead to severe cardiac diseases including cardiac arrhythmia and ...
This increase in Ca 2+ then binds to and activates another receptor, called a type 2 ryanodine receptor (RyR2), located on the membrane of a structure known as the sarcoplasmic reticulum (SR). The SR is a Ca 2+ stored within the cell and is located very close to the T-tubule. Activation of RyR2 causes it to open, releasing even more Ca 2+ into ...
While the reflex may raise heart rate by as much as 40% to 60%, [7] initial attempts to replicate Bainbridge's observations were frequently unsuccessful [8] and this inconsistency was only explained in 1955 when Coleridge and Linden found that the type of heart rate response (increase or decrease) depended on the resting heart rate and the rate ...