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  2. Anti–citrullinated protein antibody - Wikipedia

    en.wikipedia.org/wiki/Anti–citrullinated...

    Moreover, analysis of the correlation of anti-CCP antibody titre with RA disease activity yielded conflicting results. [13] [14] However, novel test systems utilizing ACPA have been developed. Citrullinated vimentin is a very promising autoantigen in RA, and a suitable tool for studying this systemic autoimmune disease. Vimentin is secreted and ...

  3. Mutated citrullinated vimentin - Wikipedia

    en.wikipedia.org/wiki/Mutated_citrullinated_Vimentin

    Anti-MCV antibodies are a member of the ACPA family, a group of the so-called antibodies to citrullinated protein/peptide antigens. Rheumatoid arthritis is an autoimmune disorder. Detection of specific autoantibodies (antibodies directed against the body’s own tissue) such as rheumatoid factors and ACPAs may provide indication of the disease.

  4. Rheumatoid arthritis - Wikipedia

    en.wikipedia.org/wiki/Rheumatoid_arthritis

    When RA is clinically suspected, a physician may test for rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPAs measured as anti-CCP antibodies). [ 76 ] : 382 The test is positive approximately two-thirds of the time, but a negative RF or CCP antibody does not rule out RA; rather, the arthritis is called seronegative , which ...

  5. Citrullination - Wikipedia

    en.wikipedia.org/wiki/Citrullination

    The presence of anti-citrullinated protein antibody is a standard test for rheumatoid arthritis, and it is associated with more severe disease. Citrullinated proteins are also found in the cellular debris accompanying the destruction of cells in alzheimer disease, and after smoking cigarettes. So citrullination seems to be part of the mechanism ...

  6. Anti-centromere antibodies - Wikipedia

    en.wikipedia.org/wiki/Anti-centromere_antibodies

    The specificity of this test is >98%. Thus, a positive anti-centromere antibody finding is strongly suggestive of limited systemic scleroderma. Anti-centromere antibodies present early in the course of disease and are notably predictive of limited cutaneous involvement and a decreased likelihood of aggressive internal organ involvement, such as ...

  7. Palindromic rheumatism - Wikipedia

    en.wikipedia.org/wiki/Palindromic_rheumatism

    Palindromic rheumatism is a disease of unknown cause. It has been suggested that it is an abortive form of rheumatoid arthritis (RA), since anti-cyclic citrullinated peptide antibodies (anti-CCP) and antikeratin antibodies (AKA) are present in a high proportion of patients, as is the case in rheumatoid arthritis. [6]

  8. Parents of 6-Year-Old Told to 'Wait It Out' After Doctors ...

    www.aol.com/parents-6-old-told-wait-183224859.html

    The boy had a sore throat, cough, and swollen glands — but it was the bruising on his back that led doctors to test for leukemia. His mom, Wendy, advises parents to "trust their guts and to keep ...

  9. Undifferentiated connective tissue disease - Wikipedia

    en.wikipedia.org/wiki/Undifferentiated...

    Signs and symptoms which (a) are suggestive of a connective tissue disease, but (b) do not meet the criteria of any defined connective tissue diseases, [12] and (c) have lasted for at least three years. (Note if less than three years may be regarded as early UCTD). Positive ANA test on two different occasions. [3] [18]