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Patients with cSLE may present with tissue-injuring and blood vessel-injuring (termed lupus vasculitis) inflammation in the: a) kidneys, causing various types of kidney damages e.g., lupus nephritis and kidney failure, and thereby hypertension, i.e., high blood pressure; [1] [11] [12] b) central nervous system, causing headaches, seizures ...
Lupus erythematosus is a collection of autoimmune diseases in which the human immune system becomes hyperactive and attacks healthy tissues. [1] Symptoms of these diseases can affect many different body systems, including joints, skin, kidneys, blood cells, heart, and lungs.
A breakthrough was made in 1948 with the discovery of the LE cell (the lupus erythematosus cell—a misnomer, as it occurs with other diseases as well). Discovered by a team of researchers at the Mayo Clinic, they discovered that the white blood cells contained the nucleus of another cell that was pushing against the white's cell proper nucleus.
A new treatment is being trialled for the autoimmune condition
Common symptoms include extreme fatigue, joint pain or skin rashes. In rare cases, the disease may lead to kidney or heart damage, or weaken the immune system so the body can’t fight off infections.
Subacute cutaneous lupus erythematosus (SCLE ) is a clinically distinct subset of cases of lupus erythematosus that is most often present in white women aged 15 to 40, consisting of skin lesions that are scaly and evolve as poly-cyclic annular lesions or plaques similar to those of plaque psoriasis. [1]
The closest thing to a telltale sign of the disease is the so-called butterfly rash (or malar rash) — a red rash across the cheeks and the bridge of the nose that appears after sun exposure.
Second is a discoid rash, which is chronic rash in sun-exposed areas that are plaque-like or forms a sort of patchy redness and can scar. Finally, a general photosensitivity of the skin—essentially a catch-all category for other rashes that happen to sun-exposed areas—typically only lasting a couple of days.
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