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Anti-centromere antibodies are found in approximately 60% of patients with limited systemic scleroderma and in 15% of those with the diffuse form of scleroderma. The specificity of this test is >98%. Thus, a positive anti-centromere antibody finding is strongly suggestive of limited systemic scleroderma.
Main antinuclear antibody patterns on immunofluorescence. [4] CREST syndrome typically displays the centromere pattern. CREST is not easily diagnosed as it closely mimics symptoms of other connective tissue and autoimmune diseases. Diagnoses are usually given when a patient presents two or more of the five major clinical symptoms. [5]
In this diagram of a duplicated chromosome, (2) identifies the centromere—the region that joins the two sister chromatids, or each half of the chromosome. In prophase of mitosis, specialized regions on centromeres called kinetochores attach chromosomes to spindle fibers. The centromere links a pair of sister chromatids together during cell ...
1059 12616 Ensembl ENSG00000125817 ENSMUSG00000068267 UniProt P07199 P27790 RefSeq (mRNA) NM_001810 NM_007682 RefSeq (protein) NP_001801 NP_031708 Location (UCSC) Chr 20: 3.78 – 3.79 Mb Chr 2: 131.02 – 131.02 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Centromere protein B also known as major centromere autoantigen B is an autoantigen protein of the cell nucleus. In humans ...
Immunofluorescence pattern of SS-A and SS-B antibodies. Produced using serum from a patient on HEp-20-10 cells with a FITC conjugate. Anti-SSA autoantibodies (anti–Sjögren's-syndrome-related antigen A autoantibodies, also called anti-Ro, or similar names including anti-SSA/Ro, anti-Ro/SSA, anti–SS-A/Ro, and anti-Ro/SS-A) are a type of anti-nuclear autoantibodies that are associated with ...
An extractable nuclear antigen panel, or an ENA panel, tests for presence of autoantibodies in the blood that react with proteins in the cell nucleus.It is usually done as a follow-up to a positive antinuclear antibody test and when one is showing symptoms of an autoimmune disorder.
This is the highest dilution of the serum at which autoantibodies are still detectable. Positive autoantibody titres at a dilution equal to or greater than 1:160 are usually considered as clinically significant. Positive titres of less than 1:160 are present in up to 20% of the healthy population, especially the elderly.
Anti Scl-70 antibodies (also called anti-topoisomerase I after the type I topoisomerase target [1]) is a type of antinuclear autoantibody seen mainly in diffuse systemic scleroderma, but is also seen the more limited form of systemic scleroderma called CREST syndrome. [2]