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Clopidogrel, sold under the brand name Plavix among others, is an antiplatelet medication used to reduce the risk of heart disease and stroke in those at high risk. [10] It is also used together with aspirin in heart attacks and following the placement of a coronary artery stent ( dual antiplatelet therapy ). [ 10 ]
Side effects may include bleeding, most commonly from the nose, gastrointestinal tract (GI) or genitourinary system. [2] Compared to the risk of bleeding with warfarin use, direct factor Xa inhibitors have a higher risk of GI bleeding, but lower risk of bleeding in the brain . [ 2 ]
Side effects [23] Increased bleeding risk; Rash (Clopidogrel) Dual antiplatelet therapy with aspirin for a reduction of risk of major adverse cardiac events for all acute coronary syndrome patients [24] An image of clopidogrel tablet package (Plavix) Caution. Metabolism of P2Y12 inhibitors requires CYP450 enzymes → potential drug interactions
For patients with high risk of gastrointestinal bleeding, the risk outweighs the possible adverse cardiovascular effects. It should therefore be recommended to those patients to combine clopidogrel with less CYP2C19 inhibiting PPI's, such as pantoprazole.
These side effects are serious and some of them are permanent, and many remain a crucial concern for companies and healthcare professionals and substantial efforts are being encouraged to reduce the potential risks for future antipsychotics through more clinical trials and drug development.
Most potential side effects of Cialis are dose-dependent, meaning they become more common at higher doses. Sorry to be a broken record, but only use the dosage of Cialis prescribed to you.
Like other SSRIs, sertraline can cause a range of possible side effects that typically occur during the first few weeks of treatment, including: Nausea. Fatigue and tiredness.
Serious side effects may include angioedema, Clostridioides difficile infection, and pneumonia. [11] Use in pregnancy appears to be safe, while safety during breastfeeding is unclear. [ 3 ] Esomeprazole is the ( S )-(−)- enantiomer (or less specifically the S- isomer ) of omeprazole . [ 11 ]
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