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Tolnaftate is one example of thiocarbamate antifungals. Tolnaftate Tolnaftate is a topically used antifungal for treating or preventing superficial dermatophyte infections, also known as skin infections, ringworm or tinea, and pityriasis versicolor. It is available in gel, solution, powder, ointment, or cream. Repeated treatment may be required ...
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Tolnaftate [1] sold under the brand name TAGRID among, others is a synthetic thiocarbamate used as an anti-fungal agent that may be sold without medical prescription in most jurisdictions. It is supplied as a cream, powder, spray, liquid, and liquid aerosol . [ 2 ]
There are many topical antifungal drugs useful in the treatment of athlete's foot including: miconazole nitrate, clotrimazole, tolnaftate (a synthetic thiocarbamate), terbinafine hydrochloride, [18] butenafine hydrochloride and undecylenic acid.
Antifungal treatments include topical agents such as miconazole, terbinafine, clotrimazole, ketoconazole, or tolnaftate applied twice daily until symptoms resolve — usually within one or two weeks. [16] Topical treatments should then be continued for a further 7 days after resolution of visible symptoms to prevent recurrence.
A systematic review of the medical literature comparing treatments for ringworm and jock itch was generally critical of the quality of data available. It concluded that there was "insufficient evidence to determine if Whitfield's ointment, a widely used agent, is effective", [ 6 ] implying that the studies were of poor quality and therefore ...
Clotrimazole is an imidazole derivative that works by inhibiting the growth of individual Candida or fungal cells by altering the permeability of the fungal cell wall. [7] The drug impairs the biosynthesis of ergosterol , a critical component of the fungal cell membrane, by inhibiting the P450 enzyme lanosterol 14-alpha demethylase. [ 19 ]
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