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Ketotifen is an antihistamine medication and a mast cell stabilizer used to treat allergic conditions such as conjunctivitis, asthma, and urticaria (hives).Ketotifen is available in ophthalmic (eye drops or drug-eluting contact lenses) and oral (tablets or syrup) forms: the ophthalmic form relieves eye itchiness and irritation associated with seasonal allergies, while the oral form helps ...
Norketotifen is a pharmaceutical medication which is not yet approved for use and is undergoing clinical trials. It is a biologically active demethylated metabolite of ketotifen and has a similar potency as ketotifen as an antihistamine H 1 medication and a mast cell stabilizer, yet is devoid of severe sedative effects of ketotifen, potentially allowing for higher doses to be administered ...
Ketotifen is available without a prescription in some countries. [ citation needed ] However, studies demonstrates that olopatadine is more effective than ketotifen in reducing the itching associated with allergic conjunctivitis in the antigen challenge model.
10-Hydroxyketotifen (WR621365) [1] is a biologically inactive metabolite of ketotifen. [2] [3] [4] Despite the mainstream scientific consensus that 10-hydroxyketotifen is a biologically inactive compound, its pharmacological properties are not very well studied outside the context of ketotifen, therefore, 10-hydroxyketotifen may still possess biological activity similarly to norketotifen ...
[2] [5] Some drugs that have been successfully loaded via this method are: timolol, norfloxacin, ketotifen, polyvinlypyrrolidone, and hyaluronic acid. [5] [11] [12] The molecular structures of each of these drugs are shown below in the index of important scientific terminology.
Clemastine is an antihistamine with anticholinergic and sedative effects. Antihistamines competitively bind to histamine receptor sites, thus reducing the neurotransmitter's effects. [9]
In 2006, Alimera Sciences developed and submitted for U.S. Food and Drug Administration approval an application for a prescription to over-the-counter drug switch of 0.025% ketotifen fumarate, for the temporary relief of ocular itch.
Rupatadine fumarate has been approved for the treatment of allergic rhinitis and chronic urticaria in adults and children over 12 years. It is available as round, light salmon coloured tablets containing 10 mg of rupatadine (as fumarate) to be administered orally, once a day.
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