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Calcitriol is a hormone and the active form of vitamin D, normally made in the kidney. [8] [9] [10] It is also known as 1,25-dihydroxycholecalciferol.It binds to and activates the vitamin D receptor in the nucleus of the cell, which then increases the expression of many genes. [11]
Vitamin D 3 (cholecalciferol) is produced industrially by exposing 7-dehydrocholesterol to UVB and UVC light, followed by purification. The 7-dehydrocholesterol is sourced as an extraction from lanolin, a waxy skin secretion in sheep's wool. [184] Vitamin D 2 (ergocalciferol) is produced in a similar way using ergosterol from yeast as a ...
CYP24A1 is expressed in tissues which are considered targets for vitamin D, including kidney, intestine and bone. Transcription of the CYP24A1 gene is markedly inducible by 1,25-(OH) 2 D 3 binding to the vitamin D receptor. [6] The gene has a strong, positive vitamin D response element in the promoter.
13115 Ensembl ENSG00000111012 ENSMUSG00000006724 UniProt O15528 O35084 RefSeq (mRNA) NM_000785 NM_010009 RefSeq (protein) NP_000776 NP_034139 Location (UCSC) Chr 12: 57.76 – 57.77 Mb Chr 10: 126.88 – 126.89 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse calcidiol 1-monooxygenase Identifiers EC no. 1.14.15.18 CAS no. 9081-36-1 Databases IntEnz IntEnz view BRENDA BRENDA entry ...
Cholecalciferol is a form of vitamin D which is naturally synthesized in skin and functions as a pro-hormone, being converted to calcitriol. This is important for maintaining calcium levels and promoting bone health and development. [4] As a medication, cholecalciferol may be taken as a dietary supplement to prevent or to treat vitamin D ...
This latter form of vitamin D is the active hormone which stimulates calcium uptake from the intestine. [22] Via the kidney, PTH enhances the absorption of calcium in the intestine by increasing the production of activated vitamin D. Vitamin D activation occurs in the kidney.
Vitamin D-dependent calcium binding proteins were discovered in the cytosolic fractions of chicken intestine, and later in mammalian intestine and kidney, by researchers including Robert Wasserman of Cornell University. [10] [11] Such proteins bound calcium in the micromolar range and were greatly reduced in vitamin D-deficient
The kidney influences the plasma ionized calcium concentration in yet another manner. It processes vitamin D 3 into calcitriol, the active form that is most effective in promoting the intestinal absorption of calcium. This conversion of vitamin D 3 into calcitriol, is also promoted by high plasma parathyroid hormone levels. [4] [5]
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