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  2. Oxidative decarboxylation - Wikipedia

    en.wikipedia.org/wiki/Oxidative_decarboxylation

    Oxidative metabolism entails the further catabolism of pyruvate. The pyruvate dehydrogenase, or PDH complex carries out the oxidative decarboxylation process that generates acetyl CoA from pyruvate. The PDH complex serves as the link between glycolysis and the citric acid cycle and is required for oxidative metabolism.

  3. Pyruvate decarboxylation - Wikipedia

    en.wikipedia.org/wiki/Pyruvate_decarboxylation

    Pyruvate decarboxylation or pyruvate oxidation, also known as the link reaction (or oxidative decarboxylation of pyruvate [1]), is the conversion of pyruvate into acetyl-CoA by the enzyme complex pyruvate dehydrogenase complex. [2] [3] The reaction may be simplified as: Pyruvate + NAD + + CoA → Acetyl-CoA + NADH + CO 2

  4. Decarboxylation - Wikipedia

    en.wikipedia.org/wiki/Decarboxylation

    In the related Hammick reaction, uncatalyzed decarboxylation of a picolinic acid gives a stable carbene that attacks a carbonyl electrophile. Oxidative decarboxylations are generally radical reactions. These include the Kolbe electrolysis and Hunsdiecker-Kochi reactions. The Barton decarboxylation is an unusual radical reductive decarboxylation.

  5. Branched-chain alpha-keto acid dehydrogenase complex

    en.wikipedia.org/wiki/Branched-chain_alpha-keto...

    This enzyme complex catalyzes the oxidative decarboxylation of branched, short-chain alpha-ketoacids. BCKDC is a member of the mitochondrial α-ketoacid dehydrogenase complex family, which also includes pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase, key enzymes that function in the Krebs cycle.

  6. Isocitrate dehydrogenase - Wikipedia

    en.wikipedia.org/wiki/Isocitrate_dehydrogenase

    Isocitrate dehydrogenase (IDH) (EC 1.1.1.42) and (EC 1.1.1.41) is an enzyme that catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO 2. This is a two-step process, which involves oxidation of isocitrate (a secondary alcohol ) to oxalosuccinate (a ketone ), followed by the ...

  7. Pyruvate dehydrogenase complex - Wikipedia

    en.wikipedia.org/wiki/Pyruvate_dehydrogenase_complex

    Pyruvate dehydrogenase complex (PDC) is a complex of three enzymes that converts pyruvate into acetyl-CoA by a process called pyruvate decarboxylation. [1] Acetyl-CoA may then be used in the citric acid cycle to carry out cellular respiration, and this complex links the glycolysis metabolic pathway to the citric acid cycle. Pyruvate ...

  8. Malate dehydrogenase (decarboxylating) - Wikipedia

    en.wikipedia.org/wiki/Malate_dehydrogenase_(de...

    Malate dehydrogenase (decarboxylating) (EC 1.1.1.39) or NAD-malic enzyme (NAD-ME) is an enzyme that catalyzes the chemical reaction (S)-malate + NAD + pyruvate + CO 2 + NADH. Thus, the two substrates of this enzyme are (S)-malate and NAD +, whereas its three products are pyruvate, CO 2, and NADH.

  9. Pyruvate decarboxylase - Wikipedia

    en.wikipedia.org/wiki/Pyruvate_decarboxylase

    Pyruvate decarboxylase is an enzyme (EC 4.1.1.1) that catalyses the decarboxylation of pyruvic acid to acetaldehyde.It is also called 2-oxo-acid carboxylase, alpha-ketoacid carboxylase, and pyruvic decarboxylase. [1]