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As a result, different GLP-1 agonist drugs are modified in various ways to extend the half-life, resulting in drugs that can be dosed multiple times per day, daily, weekly, or less often. [29] Most synthetic GLP-1 agonists are delivered via subcutaneous injection , which is a barrier to their use and reason for discontinuation. [ 37 ]
Drugs used in diabetes treat types of diabetes mellitus by decreasing glucose levels in the blood. With the exception of insulin , most GLP-1 receptor agonists ( liraglutide , exenatide , and others), and pramlintide , all diabetes medications are administered orally and are thus called oral hypoglycemic agents or oral antihyperglycemic agents.
Less glucose is absorbed because the carbohydrates are not broken down into glucose molecules. In diabetic patients, the short-term effect of these drugs therapies is to decrease current blood glucose levels: the long-term effect is a small reduction in hemoglobin A1c level. [19]
This article showcases a curated list of standout studies over the last week on topics such as cholesterol, GLP-1 drugs for weight loss, and supplements for heart health.
Insulin glargine is a long-acting modified form of medical insulin used in the management of type 1 and type 2 diabetes. [90] It is administered through subcutaneous injection. Its effects typically begin within an hour of injection. [90] Common side effects include (hypoglycemia, issues at the injection site, itchiness, and weight gain. [90]
Semaglutide, which is commonly used to manage type 2 diabetes, is intended for long-term use. Side effects from doing so are rare.
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