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Video of relevant anatomy Coronal slices of human brain showing the basal ganglia. White matter is shown in dark gray, gray matter is shown in light gray. Anterior: striatum, globus pallidus (GPe and GPi) Posterior: subthalamic nucleus (STN), substantia nigra (SN) The basal ganglia form a fundamental component of the cerebrum.
The basal ganglia are located bilaterally, and have rostral and caudal divisions. The putamen is located in the rostral division as part of the striatum. The basal ganglia receive input from the cerebral cortex, via the striatum. This is a transverse section of the striatum from a structural MR image.
The human brain is the central organ of the nervous system, and with the spinal cord, comprises the central nervous system. It consists of the cerebrum, the brainstem and the cerebellum. The brain controls most of the activities of the body, processing, integrating, and coordinating the information it receives from the sensory nervous system ...
The subthalamic nucleus (STN) is a small lens-shaped nucleus in the brain where it is, from a functional point of view, part of the basal ganglia system. In terms of anatomy, it is the major part of the subthalamus. As suggested by its name, the subthalamic nucleus is located ventral to the thalamus.
The substantia nigra (SN) is a basal ganglia structure located in the midbrain that plays an important role in reward and movement. Substantia nigra is Latin for "black substance", reflecting the fact that parts of the substantia nigra appear darker than neighboring areas due to high levels of neuromelanin in dopaminergic neurons. [1]
The external capsule is a series of white matter fiber tracts in the brain. These fibers run between the most lateral (toward the side of the head) segment of the lentiform nucleus (more specifically the putamen) and the claustrum. The white matter of the external capsule contains fibers known as corticocortical association fibers.
The globus pallidus (GP), also known as paleostriatum or dorsal pallidum, [1] is a major component of the subcortical basal ganglia in the brain.It consists of two adjacent segments, one external (or lateral), known in rodents simply as the globus pallidus, and one internal (or medial).
The image shows dopaminergic pathways of the human brain in normal condition (left) and Parkinsons Disease (right). Red Arrows indicate suppression of the target, blue arrows indicate stimulation of target structure. (Pallidothalamic connections visible but not labeled, as red line from GPi to THA.)