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The way in which TMPyP4 binds to G4's is similar to MM41, with the ring stacking onto the external G-quartet and side chains associating to the loops of G4's. [ 76 ] When designing ligands to be bound to G-quadruplexes, the ligands have a higher affinity for parallel folded G-quadruplexes.
This DNAzyme cleaves complementary RNAs efficiently in a sequence specific manner between an unpaired purine and a paired pyrimidine. DNAzymes targeting AU or GU vs. GC or AC are more effective. Furthermore, the RNA cleavage rates have been shown to increase after the introduction of intercalators or the substitution of deoxyguanine with ...
In molecular biology, a guanine tetrad (also known as a G-tetrad or G-quartet) is a structure composed of four guanine bases in a square planar array. [1] [2] They most prominently contribute to the structure of G-quadruplexes, where their hydrogen bonding stabilizes the structure.
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Escherichia virus G4 is a bacteriophage that infects E. coli. [1] First isolated in 1973, the phage was originally isolated from samples of raw sewage and has 5,577 nucleotides. Its isometric capsid contains a single-stranded circular genome of about 5.5 kbp .
The 3C-like protease (3CL pro) or main protease (M pro), formally known as C30 endopeptidase or 3-chymotrypsin-like protease, [2] is the main protease found in coronaviruses.It cleaves the coronavirus polyprotein at eleven conserved sites.
The DNAzyme logic gate changes its structure when it binds to a matching oligonucleotide and the fluorogenic substrate it is bonded to is cleaved free. While other materials can be used, most models use a fluorescence-based substrate because it is very easy to detect, even at the single molecule limit. [ 39 ]
192663 Ensembl ENSG00000172350 ENSMUSG00000032131 UniProt Q9H172 Q91WA9 RefSeq (mRNA) NM_001142505 NM_022169 NM_001348191 NM_001348192 NM_138955 RefSeq (protein) NP_001135977 NP_071452 NP_001335120 NP_001335121 NP_620405 Location (UCSC) Chr 11: 119.15 – 119.16 Mb Chr 9: 44.18 – 44.2 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse ATP-binding cassette sub-family G member 4 is a ...