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  2. Reuptake - Wikipedia

    en.wikipedia.org/wiki/Reuptake

    A synapse during re-uptake. Note that some neurotransmitters are lost and not reabsorbed. Reuptake is the reabsorption of a neurotransmitter by a neurotransmitter transporter located along the plasma membrane of an axon terminal (i.e., the pre-synaptic neuron at a synapse) or glial cell after it has performed its function of transmitting a neural impulse.

  3. Selective reabsorption - Wikipedia

    en.wikipedia.org/wiki/Selective_reabsorption

    Selective reabsorption is the process whereby certain molecules (e.g. ions, glucose and amino acids), after being filtered out of the capillaries along with nitrogenous waste products (i.e. urea) and water in the glomerulus, are reabsorbed from the filtrate as they pass through the nephron. [1]

  4. Selective serotonin reuptake inhibitor - Wikipedia

    en.wikipedia.org/wiki/Selective_serotonin...

    Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions. SSRIs increase the extracellular level of the neurotransmitter serotonin by limiting its reabsorption (reuptake) into the ...

  5. Neurotransmitter - Wikipedia

    en.wikipedia.org/wiki/Neurotransmitter

    Excessive glutamate release can overstimulate the brain and lead to excitotoxicity causing cell death resulting in seizures or strokes. [22] Excitotoxicity has been implicated in certain chronic diseases including ischemic stroke , epilepsy , amyotrophic lateral sclerosis , Alzheimer's disease , Huntington disease , and Parkinson's disease .

  6. Reuptake inhibitor - Wikipedia

    en.wikipedia.org/wiki/Reuptake_inhibitor

    Escitalopram, a selective serotonin reuptake inhibitor (SSRI) used as an antidepressant.. Reuptake inhibitors (RIs) are a type of reuptake modulators.It is a drug that inhibits the plasmalemmal transporter-mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron.

  7. Glutamate receptor - Wikipedia

    en.wikipedia.org/wiki/Glutamate_receptor

    Glutamate (the conjugate base of glutamic acid) is abundant in the human body, but particularly in the nervous system and especially prominent in the human brain where it is the body's most prominent neurotransmitter, the brain's main excitatory neurotransmitter, and also the precursor for GABA, the brain's main inhibitory neurotransmitter. [2]

  8. Blood–brain barrier - Wikipedia

    en.wikipedia.org/wiki/Blood–brain_barrier

    The blood–brain barrier (BBB) is a highly selective semipermeable border of endothelial cells that regulates the transfer of solutes and chemicals between the circulatory system and the central nervous system, thus protecting the brain from harmful or unwanted substances in the blood. [1]

  9. Drug delivery to the brain - Wikipedia

    en.wikipedia.org/wiki/Drug_delivery_to_the_brain

    The blood–brain barrier is formed by special tight junctions between endothelial cells lining brain blood vessels. Blood vessels of all tissues contain this monolayer of endothelial cells, however only brain endothelial cells have tight junctions preventing passive diffusion of most substances into the brain tissue. [1]