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Guanosine-5'-triphosphate (GTP) is a purine nucleoside triphosphate.It is one of the building blocks needed for the synthesis of RNA during the transcription process. Its structure is similar to that of the guanosine nucleoside, the only difference being that nucleotides like GTP have phosphates on their ribose sugar.
The binding of GTP to the GTPase results in the release of the GEF, which can then activate a new GTPase. [ 5 ] [ 6 ] Thus, GEFs both destabilize the GTPase interaction with GDP and stabilize the nucleotide-free GTPase until a GTP molecule binds to it. [ 7 ]
Phosducin-transducin beta-gamma complex. Beta and gamma subunits of G-protein are shown by blue and red, respectively. Guanosine diphosphate Guanosine triphosphate. G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior.
Protein-synthesizing GTPases (EC 3.6.5.3, elongation factor (EF), initiation factor (IF), peptide-release or termination factor) are enzymes involved in mRNA translation into protein by the ribosome, with systematic name GTP phosphohydrolase (mRNA-translation-assisting).
G proteins can bind either GDP or GTP. When bound to GDP, G proteins are inactive. When a ligand binds a GPCR, an allosteric change in the G protein is triggered, causing GDP to leave and be replaced by GTP. [39] GTP activates the alpha subunit of the G protein, causing it to dissociate from the G protein and act as a downstream effector. [39]
GTPgammaS (GTPγS, guanosine 5'-O-[gamma-thio]triphosphate) is a non-hydrolyzable or slowly hydrolyzable G-protein-activating analog of guanosine triphosphate (GTP). Many GTP binding proteins demonstrate activity when bound to GTP, and are inactivated via the hydrolysis of the phosphoanhydride bond that links the γ-phosphate to the remainder of the nucleotide, leaving a bound guanosine ...
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GPRS Tunnelling Protocol (GTP) is a group of IP-based communications protocols used to carry general packet radio service (GPRS) within GSM, UMTS, LTE and 5G NR radio networks. In 3GPP architectures, GTP and Proxy Mobile IPv6 based interfaces are specified on various interface points. GTP can be decomposed into separate protocols, GTP-C, GTP-U ...
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