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Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
A traditional method to evaluate druglikeness is to check compliance of Lipinski's rule of five, which covers the numbers of hydrophilic groups, molecular weight and hydrophobicity. Since the drug is transported in aqueous media like blood and intracellular fluid, it has to be sufficiently water-soluble in the absolute sense (i.e. must have a ...
Christopher A. Lipinski is a medicinal chemist who is working at Pfizer, Inc. [1] He is known for his "rule of five" , an algorithm that predicts drug compounds that are likely to have oral activity. [ 1 ]
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This cheat sheet is the aftermath of hours upon hours of research on all of the teams in this year’s tournament field. I’ve listed each teams’ win and loss record, their against the
Download as PDF; Printable version; In other projects Wikimedia Commons; Wikidata item; ... Lipinski's rule of five; Looney 11 rule; M. Markovnikov's rule; Moore's law;
The definitions of hydrogen bond donors and acceptors used to apply Lipinski's Rule of Five [6] are easily coded in SMARTS. Donors are defined as nitrogen or oxygen atoms that have at least one directly bonded hydrogen atom: [N,n,O;!H0] or [#7,#8;!H0] (aromatic oxygen cannot have a bonded hydrogen)
Bill Lipinski (born 1937), Polish-American politician; Christopher A. Lipinski, originator of Lipinski's rule of five to evaluate druglikeness; Dan Lipinski (born 1966), Polish-American politician; Dariusz Lipiński (born 1955), Polish politician; Edward Lipiński (economist) (1888-1986), Polish economist; Jacek Lipiński (born 1966), Polish ...