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5-HTP is produced from the amino acid tryptophan through the action of the enzyme tryptophan hydroxylase. Tryptophan hydroxylase is one of the biopterin-dependent aromatic amino acid hydroxylases. Production of 5-HTP is the rate-limiting step in 5-HT (serotonin) synthesis. 5-HTP is normally rapidly converted to 5-HT by amino acid decarboxylase. [1]
MDMA is an empathogenic-entactogenic and serotonergic psychotropic drug used primarily for recreational, though sometimes also therapeutic, purposes.Among users of MDMA, the serotonergic effects of the drug are often of particular interest and concern: After consuming MDMA, serotonin concentrations are greatly reduced in the brain. 5-HTP is necessary for serotonin production and its ...
Changed unsupported conclusion in 3rd para of this section from, "5-HTP can cause hypertension by increasing plasma renin activity", to "5-HTP was found to increase plasma renin activity in rats". The cited article specifically says, "At the doses used, serotonin decreased mean blood pressure and colonic temperature of unanesthetized rats while ...
Similar to how Omega-3-packed foods may boost cholesterol, menu items with “good” fats (like legumes, salmon, etc.) may help reduce diseases that cause chronic inflammation. You Might Also Like
Vitamin C is a powerful antioxidant that can help reduce inflammation and oxidative stress, two factors that can hamper weight loss, according to a review in the International Journal of Medical ...
The amino acid 5-HTP, or 5-hydroxytryptophan, has been anecdotally reported to be a mild anaphrodisiac, as has the serotonergic empathogen MDMA, popularly known as "ecstasy". However, systematic study of these chemicals is lacking, due to the off-patent nature of 5-HTP, and the legal control of MDMA.
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Analogously to phenylalanine hydroxylase and tyrosine hydroxylase, this enzyme uses (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (BH 4) and dioxygen as cofactors. [ 2 ] In humans, the stimulation of serotonin production by administration of tryptophan has an antidepressant effect [ 3 ] [ 4 ] and inhibition of tryptophan hydroxylase (e.g. by p ...
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